N-acetyltransferase 9

NAT9
Identifiers
Aliases	NAT9, EBSP, hNATL, N-acetyltransferase 9 (putative)
External IDs	OMIM: 620913; MGI: 1913426; GeneCards: NAT9
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,776,367 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,187,859 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; right ovary; ; left ovary; ; right hemisphere of cerebellum; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; canal of the cervix;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; granulocyte; ; spermatid; ; neural layer of retina; ; right kidney; ; muscle of thigh; ; yolk sac; ; proximal tubule; ; left lobe of liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; acyltransferase activity; protein binding; acyltransferase activity, transferring groups other than amino-acyl groups; N-acetyltransferase activity;
Cellular component	protein-containing complex;
Biological process	N-terminal protein amino acid acetylation; protein acetylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	26151
	66176
	ENSG00000109065
	ENSMUSG00000015542
	Q9BTE0
	Q3UG98
NM_001305077; NM_001305078; NM_001305079; NM_001305080; NM_001305081;
	NM_001305082; NM_001305083; NM_001305084; NM_001305085; NM_001305086; NM_001305087; NM_001305088; NM_015654
	NM_025400
NP_001292006; NP_001292007; NP_001292008; NP_001292009; NP_001292010;
	NP_001292011; NP_001292012; NP_001292013; NP_001292014; NP_001292015; NP_001292016; NP_001292017; NP_056469
	NP_079676; NP_001349818; NP_001349819; NP_001349820; NP_001349821
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha/beta-tubulin-N-acetyltransferase 9, also called N-acetyltransferase 9 (NAT9), is an enzyme that in humans is encoded by the NAT9 gene. The enzyme functions to acetylate the proteins alpha- and beta-tubulin at N-terminal residues. In particular, it catalyzes the following reaction (EC 2.3.1.308):

N-terminal L-methionyl-[tubulin] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[tubulin] + CoA + H⁺

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109065 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015542 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, Gordon D, Heffernan M, Daw JA, Robarge J, Ott J, Kwok PY, Menter A, Bowcock AM (Dec 2003). "A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis". Nat Genet. 35 (4): 349–56. doi:10.1038/ng1268. PMID 14608357. S2CID 22368199.
↑ "Entrez Gene: NAT9 N-acetyltransferase 9".
↑ "Alpha/beta-tubulin-N-acetyltransferase 9". UniProt consortium. Retrieved 2026-10-08.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000109065 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015542 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14608357-5] Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, Gordon D, Heffernan M, Daw JA, Robarge J, Ott J, Kwok PY, Menter A, Bowcock AM (Dec 2003). "A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis". Nat Genet. 35 (4): 349–56. doi:10.1038/ng1268. PMID 14608357. S2CID 22368199.

[entrez-6] "Entrez Gene: NAT9 N-acetyltransferase 9".

[7] "Alpha/beta-tubulin-N-acetyltransferase 9". UniProt consortium. Retrieved 2026-10-08.

N-acetyltransferase 9

References

Further reading