NDC80

NDC80
Identifiers
Aliases	NDC80, HEC, HEC1, HsHec1, KNTC2, TID3, hskinetochore complex component, NDC80 kinetochore complex component
External IDs	OMIM: 607272; MGI: 1914302; GeneCards: NDC80
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IGP, 2VE7, 3IZ0
Gene location (Human) Chr. Chromosome 18 (human) Band 18p11.32 Start 2,571,557 bp End 2,616,635 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 E1.3 Start 71,803,095 bp End 71,833,852 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence gonad testicle trabecular bone amniotic fluid bone marrow secondary oocyte sperm seminal vesicula Top expressed in zygote secondary oocyte tail of embryo genital tubercle primary oocyte spermatocyte ventricular zone epiblast maxillary prominence mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton protein binding identical protein binding Cellular component cytosol membrane chromosome Ndc80 complex chromosome, centromeric region nucleus kinetochore nucleoplasm centrosome Biological process chromosome segregation mitotic spindle organization cell division establishment of mitotic spindle orientation mitotic sister chromatid segregation cell cycle attachment of spindle microtubules to kinetochore sister chromatid cohesion metaphase plate congression attachment of mitotic spindle microtubules to kinetochore positive regulation of mitotic cell cycle spindle assembly checkpoint mitotic cell cycle kinetochore organization positive regulation of protein localization to kinetochore Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 10403 67052 Ensembl ENSG00000080986 ENSMUSG00000024056 UniProt O14777 Q9D0F1 RefSeq (mRNA) NM_006101 NM_023294 RefSeq (protein) NP_006092 NP_075783 Location (UCSC) Chr 18: 2.57 – 2.62 Mb Chr 17: 71.8 – 71.83 Mb PubMed search
Wikidata
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Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.

Function

Ndc80 is one of the proteins of outer kinetochore. It forms a heterotetramer with proteins NUF2, SPC25, and SPC24. This protein complex has microtubule-binding domains.

HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.

Interactions

NDC80 has been shown to interact with MIS12, NEK2 and PSMC2.