NDFIP2

NDFIP2
Identifiers
Aliases	NDFIP2, N4WBP5A, Nedd4 family interacting protein 2
External IDs	OMIM: 610041; MGI: 1923523; GeneCards: NDFIP2
Gene location (Human)
Chr.	Chromosome 13 (human)
End	79,556,077 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	105,546,732 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; skin of arm; ; sperm; ; pancreatic epithelial cell; ; Brodmann area 46; ; mucosa of ileum; ; skin of thigh; ; palpebral conjunctiva; ; jejunal mucosa; ; pons;
	Top expressed in
	habenula; ; deep cerebellar nuclei; ; medial vestibular nucleus; ; olfactory tubercle; ; submandibular gland; ; ventral tegmental area; ; pontine nuclei; ; lateral geniculate nucleus; ; left colon; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein binding; WW domain binding;
Cellular component	cytoplasm; integral component of membrane; endosome; Golgi apparatus; multivesicular body membrane; intracellular membrane-bounded organelle; membrane; Golgi membrane; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; endosome membrane;
Biological process	negative regulation of gene expression; negative regulation of protein transport; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein ubiquitination; negative regulation of transporter activity; signal transduction; vacuolar transport; metal ion transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54602
	76273
	ENSG00000102471
	ENSMUSG00000053253
	Q9NV92
	Q91ZP6
	NM_001161407; NM_019080; NM_001394685
	NM_001190989; NM_029561
	NP_001154879; NP_061953
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene.

Interactions

NDFIP2 has been shown to interact with NEDD4.

Conversely, it has also been shown that NDFIP2 does not interact with the NEDD4-2 variant in neurons of the dorsal root ganglia, but it does participate in the regulation of TRKA, TRKB, and TRKC. This could indicate a direct relationship between NDFIP2 and the cellular mechanisms of nociception.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102471 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053253 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (January 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research. 6 (5): 329–336. doi:10.1093/dnares/6.5.329. PMID 10574461.
↑ Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, et al. (August 2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". The Journal of Biological Chemistry. 277 (33): 29406–29416. doi:10.1074/jbc.M203018200. PMID 12050153.
↑ "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2".
↑ Cristillo AD, Nie L, Macri MJ, Bierer BE (September 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". The Journal of Biological Chemistry. 278 (36): 34587–34597. doi:10.1074/jbc.M304723200. PMID 12796489.
↑ Cañada-García D, Hernández-García A, Vicente-García C, Valero J, Ayon-Olivas M, Kumar S, et al. (March 2026). "Ndfip2 in TrkA-expressing sensory neurons regulates noxious mechanosensation through control of TrkA signaling and protein levels". Cell Death & Disease. 17 (1) 437. doi:10.1038/s41419-026-08670-9. hdl:10366/171519. PMC 13158297. PMID 41912490.

NDFIP2

Interactions

References

Further reading