NDST3

NDST3
Identifiers
Aliases	NDST3, HSST3, N-deacetylase/N-sulfotransferase 3, N-deacetylase and N-sulfotransferase 3
External IDs	OMIM: 603950; MGI: 1932544; GeneCards: NDST3
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	118,258,634 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	123,484,502 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; cerebellar cortex; ; cerebellar hemisphere; ; testicle; ; right hemisphere of cerebellum; ; prefrontal cortex; ; ganglionic eminence; ; nucleus accumbens; ; Brodmann area 9; ; right frontal lobe;
	Top expressed in
	cerebellar cortex; ; spermatid; ; primary visual cortex; ; seminiferous tubule; ; superior frontal gyrus; ; lumbar subsegment of spinal cord; ; neural layer of retina; ; inferior colliculi; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; catalytic activity; hydrolase activity; [heparan sulfate-glucosamine N-sulfotransferase activity]; heparan sulfate N-acetylglucosaminyltransferase activity; deacetylase activity; heparan sulfate sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane; cellular component;
Biological process	metabolism; heparin biosynthetic process; heparan sulfate proteoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; glycosaminoglycan biosynthetic process; sulfur compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9348
	83398
	ENSG00000164100
	ENSMUSG00000027977
	O95803
	Q9EQH7
	NM_004784
	NM_001293682; NM_031186
	NP_004775
	NP_001280611; NP_112463
	Wikidata
View/Edit Human	View/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)

This is a step in the production of heparin.

Clinical significance

Mutations in NDST3 have been linked to schizophrenia.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164100 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027977 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Aikawa J, Esko JD (March 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". The Journal of Biological Chemistry. 274 (5): 2690–2695. doi:10.1074/jbc.274.5.2690. PMID 9915799.
↑ "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".
1 2 "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". UniProt. Retrieved 2020-01-15.
↑ Zhang C, Lu W, Wang Z, Ni J, Zhang J, Tang W, et al. (January 2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese". Translational Psychiatry. 6 (1): e701. doi:10.1038/tp.2015.199. PMC 5068873. PMID 26731438.

Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Aikawa J, Grobe K, Tsujimoto M, Esko JD (2001). "Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4". The Journal of Biological Chemistry. 276 (8): 5876–5882. doi:10.1074/jbc.M009606200. PMID 11087757.
Boutry M, Vassarotti A, Ghislain M, Douglas M, Goffeau A (March 1984). "Isolation of the structural genes for the alpha and beta subunits of the mitochondrial ATPase from the fission yeast Schizosaccharomyces pombe". The Journal of Biological Chemistry. 259 (5): 2840–2844. doi:10.1016/S0021-9258(17)43223-6. PMID 6230352.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164100 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027977 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Aikawa_1999-5] Aikawa J, Esko JD (March 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". The Journal of Biological Chemistry. 274 (5): 2690–2695. doi:10.1074/jbc.274.5.2690. PMID 9915799.

[entrez-6] "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".

[NDST3_Bifunctional_heparan-7] 1 2 "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". UniProt. Retrieved 2020-01-15.

[8] Zhang C, Lu W, Wang Z, Ni J, Zhang J, Tang W, et al. (January 2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese". Translational Psychiatry. 6 (1): e701. doi:10.1038/tp.2015.199. PMC 5068873. PMID 26731438.

NDST3

Clinical significance

References

Further reading