NDUFAF8

NDUFAF8
Identifiers
Aliases	NDUFAF8, C17orf89, NADH:ubiquinone oxidoreductase complex assembly factor 8
External IDs	OMIM: 618461; MGI: 1913676; GeneCards: NDUFAF8
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	119,991,531 bp
Gene ontology
Molecular function	protein binding;
Cellular component	mitochondrion;
Biological process	mitochondrial respiratory chain complex I assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	284184
	208501
	ENSG00000224877
	ENSMUSG00000078572
	A1L188
	A2AMZ4
	NM_001086521
	NM_001110242
	NP_001079990; NP_001340331; NP_001340332
	NP_001103712
	Wikidata
View/Edit Human	View/Edit Mouse

NADH:ubiquinone oxidoreductase complex assembly factor 8 is a protein that in humans is encoded by the NDUFAF8 gene. This protein stabilizes NDUFAF5 during assembly of mitochondrial Complex I.

Structure

The NDUFAF8 gene is located on the q arm of chromosome 17 in position 25.3 and spans 1,987 base pairs. The gene produces a 7.756 kDa protein composed of 74 amino acids.

Function

The protein encoded by the NDUFAF8 gene is involved in the assembly of mitochondrial Complex I (NADH-ubiquinone oxidoreductase). This protein is required to stabilize NDUFAF5 during assembly of Complex I.

Interaction

NDUFAF8 has protein-protein interactions with NDUFAF5, stabilizing it.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078572 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: NADH:ubiquinone oxidoreductase complex assembly factor 8". Retrieved 2018-07-27.
1 2 3 "NDUFAF8 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 - Homo sapiens (Human) - NDUFAF8 gene & protein". www.uniprot.org. Retrieved 2018-07-27.
↑ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
↑ "Uncharacterized protein C17orf89". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 2018-07-28. Retrieved 2018-07-27.

NDUFAF8

Structure

Function

Interaction

References

Further reading