NDUFS5

NDUFS5

Identifiers

NDUFS5, CI-15k, CI15K, NADH:ubiquinone oxidoreductase subunit S5

External IDs

OMIM: 603847; MGI: 1890889; GeneCards: NDUFS5

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p34.3	Start	39,026,318 bp
Band	1p34.3	End	39,034,636 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4\|4 D2.2	Start	123,606,503 bp
Band	4\|4 D2.2	End	123,611,995 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

apex of heart

left ventricle

right auricle of heart

optic nerve

right frontal lobe

Brodmann area 9

nucleus accumbens

caudate nucleus

anterior pituitary

prefrontal cortex

Top expressed in

sternocleidomastoid muscle

right ventricle

temporal muscle

digastric muscle

triceps brachii muscle

right kidney

medial head of gastrocnemius muscle

soleus muscle

intercostal muscle

interventricular septum

More reference expression data


More reference expression data

Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity
Cellular component	mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial intermembrane space respirasome membrane mitochondrion
Biological process	mitochondrial respiratory chain complex I assembly mitochondrial electron transport, NADH to ubiquinone
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


4725


595136


ENSG00000168653


ENSMUSG00000028648


O43920


Q99LY9

RefSeq (mRNA)


NM_004552 NM_001184979


NM_001030274

RefSeq (protein)


NP_001171908 NP_004543


NP_001025445

Location (UCSC)

Chr 1: 39.03 – 39.03 Mb

Chr 4: 123.61 – 123.61 Mb

PubMed search

View/Edit Human

View/Edit Mouse

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 is an enzyme that in humans is encoded by the NDUFS5 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168653 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028648 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet. 82 (1–2): 115–9. doi:10.1159/000015082. PMID 9763677. S2CID 46818955.
↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
↑ "Entrez Gene: NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)".

Further reading

Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
Loeffen J, Smeets R, Smeitink J, et al. (1999). "The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients". J. Inherit. Metab. Dis. 22 (1): 19–28. doi:10.1023/A:1005434912463. PMID 10070614. S2CID 22326357.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Triepels RH, Hanson BJ, van den Heuvel LP, et al. (2001). "Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns". J. Biol. Chem. 276 (12): 8892–7. doi:10.1074/jbc.M009903200. hdl:2066/185667. PMID 11112787.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Huang G, Chen Y, Lu H, Cao X (2007). "Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death". Cell Death Differ. 14 (2): 327–37. doi:10.1038/sj.cdd.4402004. PMID 16826196.

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