NEGR1

NEGR1

Identifiers

NEGR1, DMML2433, IGLON4, KILON, Ntra, neuronal growth regulator 1

External IDs

OMIM: 613173; MGI: 2444846; GeneCards: NEGR1

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p31.1	Start	71,395,943 bp
Band	1p31.1	End	72,282,539 bp

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)

Band	3\|3 H4	Start	156,267,431 bp
Band	3\|3 H4	End	157,022,082 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Brodmann area 46

Brodmann area 23

occipital lobe

primary visual cortex

superior frontal gyrus

spinal ganglia

superficial temporal artery

parietal lobe

middle temporal gyrus

Achilles tendon

Top expressed in

piriform cortex

anterior amygdaloid area

cerebellar vermis

subiculum

lobe of cerebellum

ventromedial nucleus

olfactory tubercle

inferior colliculi

lateral hypothalamus

nucleus accumbens

More reference expression data

n/a

Gene ontology
Molecular function	protein binding
Cellular component	anchored component of membrane membrane extracellular region plasma membrane
Biological process	cell adhesion locomotory behavior feeding behavior positive regulation of neuron projection development cell-cell adhesion
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


257194


320840


ENSG00000172260


ENSMUSG00000040037


Q7Z3B1


Q80Z24

RefSeq (mRNA)


NM_173808


NM_001039094 NM_177274

RefSeq (protein)


NP_776169


NP_001034183 NP_796248

Location (UCSC)

Chr 1: 71.4 – 72.28 Mb

Chr 3: 156.27 – 157.02 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene.

Clinical significance

Variants of the NEGR1 gene may be associated with obesity and major depression.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172260 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040037 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S (March 1999). "Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family". J. Biol. Chem. 274 (12): 8224–30. doi:10.1074/jbc.274.12.8224. PMID 10075727.
↑ Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260. S2CID 764409.
↑ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 24–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261.
↑ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring). 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC 2860782. PMID 19478790.

Further reading

Elortza F, Mohammed S, Bunkenborg J, et al. (2006). "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment". J. Proteome Res. 5 (4): 935–43. doi:10.1021/pr050419u. PMID 16602701.
Haupt A, Thamer C, Heni M, et al. (2009). "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study". Obesity (Silver Spring). 18 (6): 1212–7. doi:10.1038/oby.2009.413. PMID 19910938.
Li S, Zhao JH, Luan J, et al. (2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies". Am. J. Clin. Nutr. 91 (1): 184–90. doi:10.3945/ajcn.2009.28403. PMID 19812171.
Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409. S2CID 45793585.
Renström F, Payne F, Nordström A, et al. (2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Bauer F, Elbers CC, Adan RA, et al. (2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference". Am. J. Clin. Nutr. 90 (4): 951–9. doi:10.3945/ajcn.2009.27781. PMID 19692490.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hom G, Graham RR, Modrek B, et al. (2008). "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX". N. Engl. J. Med. 358 (9): 900–9. doi:10.1056/NEJMoa0707865. PMID 18204098.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Yang Q, Kathiresan S, Lin JP, et al. (2007). "Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study". BMC Med. Genet. 8 (Suppl 1): S12. doi:10.1186/1471-2350-8-S1-S12. PMC 1995619. PMID 17903294.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population". J. Hum. Genet. 54 (12): 727–31. doi:10.1038/jhg.2009.106. PMID 19851340.
Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260. S2CID 764409.

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