BEX3

BEX3
Identifiers
Aliases	BEX3, Bex, DXS6984E, HGR74, NADE, NGFRAP1, brain expressed X-linked 3
External IDs	OMIM: 300361; MGI: 1338016; GeneCards: BEX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SA6
Gene location (Human)
Chr.	X chromosome (human)
End	103,378,164 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	135,172,727 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; pons; ; superior vestibular nucleus; ; middle temporal gyrus; ; Brodmann area 23; ; ventral tegmental area; ; renal medulla; ; lateral nuclear group of thalamus; ; pars compacta; ; pars reticulata;
	Top expressed in
	yolk sac; ; somite; ; mandibular prominence; ; maxillary prominence; ; dentate gyrus of hippocampal formation granule cell; ; arcuate nucleus; ; supraoptic nucleus; ; central gray substance of midbrain; ; superior cervical ganglion; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type endopeptidase activator activity involved in apoptotic process; nerve growth factor receptor binding; death receptor binding; protein binding; metal ion binding; identical protein binding;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	multicellular organism development; activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	27018
	12070
	ENSG00000166681
	ENSMUSG00000046432
	Q00994
	Q9WTZ9
	NM_206917; NM_001282674; NM_014380; NM_206915
	NM_001110233; NM_001110234; NM_009750
	NP_001269603; NP_055195; NP_996798; NP_996800
	NP_001103703; NP_001103704; NP_033880
	Wikidata
View/Edit Human	View/Edit Mouse

Protein BEX3 is a protein that in humans is encoded by the BEX3 gene (previously NGFRAP1).

Interactions

BEX3 has been shown to interact with YWHAE and Low affinity nerve growth factor receptor.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166681 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046432 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J. Biol. Chem. 275 (23): 17566–70. doi:10.1074/jbc.C000140200. PMID 10764727.
↑ Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. hdl:11858/00-001M-0000-0013-0D4C-0. PMID 2171551.
↑ "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1".
↑ Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.

Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, Duprat S, Houlgatte R, Jumeau MN, Lamy B (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511.
Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–8. Bibcode:1999FEBSL.460..191I. doi:10.1016/S0014-5793(99)01324-1. PMID 10544233.
Bilderback TR, Gazula VR, Dobrowsky RT (2001). "Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways". J. Neurochem. 76 (5): 1540–51. doi:10.1046/j.1471-4159.2001.00171.x. PMID 11238738. S2CID 37832858.
Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.
Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, Li Y, Irie S, Sato TA (2002). "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis". J. Biol. Chem. 277 (16): 13973–82. doi:10.1074/jbc.M106342200. PMID 11830582.
Tong X, Xie D, Roth W, Reed J, Koeffler HP (2003). "NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". Int. J. Oncol. 22 (6): 1357–62. doi:10.3892/ijo.22.6.1357. PMID 12739005.
Yoon K, Jang HD, Lee SY (2004). "Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis". Biochem. Biophys. Res. Commun. 319 (2): 649–54. Bibcode:2004BBRC..319..649Y. doi:10.1016/j.bbrc.2004.05.043. PMID 15178455.
Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene. 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID 15958283.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Yu Y, Wang J, Yuan H, Qin F, Wang J, Zhang N, Li YY, Liu J, Lu H (2006). "Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE". Brain Res. 1100 (1): 13–20. doi:10.1016/j.brainres.2006.05.010. PMID 16777077. S2CID 34177609.
Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, Ohno K (2007). "The TSC1 gene product hamartin interacts with NADE". Mol. Cell. Neurosci. 35 (1): 100–8. doi:10.1016/j.mcn.2007.02.007. PMID 17355907. S2CID 24058959.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166681 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046432 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10764727-5] 1 2 Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J. Biol. Chem. 275 (23): 17566–70. doi:10.1074/jbc.C000140200. PMID 10764727.

[pmid2171551-6] Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. hdl:11858/00-001M-0000-0013-0D4C-0. PMID 2171551.

[entrez-7] "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1".

[pmid11278287-8] Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.

BEX3

Interactions

References

Further reading