NIPA2

NIPA2

Identifiers

NIPA2, non imprinted in Prader-Willi/Angelman syndrome 2, SLC57A2, NIPA magnesium transporter 2

External IDs

OMIM: 608146; MGI: 1913918; GeneCards: NIPA2

Gene location (Human)

Chr.	Chromosome 15 (human)

Band	15q11.2	Start	22,838,644 bp
Band	15q11.2	End	22,869,362 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7\|7 B5	Start	55,581,035 bp
Band	7\|7 B5	End	55,612,224 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

mucosa of colon

mucosa of sigmoid colon

secondary oocyte

mucosa of ileum

nasal epithelium

rectum

right ventricle

islet of Langerhans

duodenum

Top expressed in

epithelium of small intestine

submandibular gland

gastrula

ileum

left colon

transitional epithelium of urinary bladder

interventricular septum

atrioventricular valve

jejunum

epithelium of stomach

More reference expression data


More reference expression data

Gene ontology
Molecular function	magnesium ion transmembrane transporter activity
Cellular component	integral component of membrane endosome plasma membrane early endosome membrane
Biological process	magnesium ion transmembrane transport ion transport magnesium ion transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


81614


93790


ENSG00000140157


ENSMUSG00000030452


Q8N8Q9


Q9JJC8

RefSeq (mRNA)

NM_001008860 NM_001008892 NM_001008894 NM_001184888 NM_001184889
NM_030922


NM_001256130 NM_001256131 NM_001256132 NM_001256133 NM_023647

RefSeq (protein)

NP_001008860 NP_001008892 NP_001008894 NP_001171817 NP_001171818
NP_112184


NP_001243059 NP_001243060 NP_001243061 NP_001243062 NP_076136

Location (UCSC)

Chr 15: 22.84 – 22.87 Mb

Chr 7: 55.58 – 55.61 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 is a protein that in humans is encoded by the NIPA2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140157 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030452 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chai JH, Locke DP, Greally JM, Knoll JH, Ohta T, Dunai J, Yavor A, Eichler EE, Nicholls RD (Sep 2003). "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons". Am J Hum Genet. 73 (4): 898–925. doi:10.1086/378816. PMC 1180611. PMID 14508708.
↑ "Entrez Gene: NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2".

Further reading

Bittel DC, Kibiryeva N, Butler MG (2006). "Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome". Pediatrics. 118 (4): e1276–e1283. doi:10.1542/peds.2006-0424. PMC 5453799. PMID 16982806.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lefèvre C, Bouadjar B, Karaduman A, et al. (2005). "Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis". Hum. Mol. Genet. 13 (20): 2473–2482. doi:10.1093/hmg/ddh263. hdl:11655/14560. PMID 15317751.
Glinsky GV, Glinskii AB, Stephenson AJ, et al. (2004). "Gene expression profiling predicts clinical outcome of prostate cancer". J. Clin. Invest. 113 (6): 913–923. doi:10.1172/JCI20032. PMC 362118. PMID 15067324.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.

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