Naked cuticle 2

NKD2
Identifiers
Aliases	NKD2, Naked2, Naked cuticle 2, naked cuticle homolog 2, WNT signaling pathway inhibitor, NKD inhibitor of WNT signaling pathway 2
External IDs	OMIM: 607852; MGI: 1919543; GeneCards: NKD2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,038,943 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,995,750 bp
RNA expression pattern
	Top expressed in
	upper lobe of left lung; ; right lung; ; spleen; ; skin of abdomen; ; skin of leg; ; left adrenal cortex; ; right testis; ; left testis; ; right adrenal gland; ; placenta;
	Top expressed in
	tail of embryo; ; genital tubercle; ; hand; ; hair follicle; ; foot; ; maxillary prominence; ; paraxial mesoderm; ; mandibular prominence; ; iris; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; growth factor binding; metal ion binding; protein binding; ubiquitin protein ligase binding; myosin heavy chain binding; ATPase binding;
Cellular component	cytoplasm; lateral plasma membrane; membrane; basolateral plasma membrane; cytoplasmic vesicle; cell periphery; plasma membrane; exocytic vesicle;
Biological process	Wnt signaling pathway; positive regulation of protein processing; Golgi vesicle fusion to target membrane; negative regulation of canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; exocytosis; protein localization to plasma membrane; positive regulation of protein localization to plasma membrane; negative regulation of Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	85409
	72293
	ENSG00000145506; ENSG00000276920
	ENSMUSG00000021567
	Q969F2
	Q8VE28
	NM_001271082; NM_033120
	NM_028186; NM_001347535
	NP_001258011; NP_149111
	NP_001334464; NP_082462
	Wikidata
View/Edit Human	View/Edit Mouse

Naked cuticle homolog 2 (Naked-2) is a protein which in humans is encoded by the gene NKD2. Naked-2 is one of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway. Both naked-1 and naked-2 proteins can bind to Dishevelled proteins (DVL1, DVL2, DVL3), but only naked-2 can bind to the EGF-ligand family member TGF alpha and regulate its polarized secretion in cultured epithelial cells.

Sources

1 2 3 ENSG00000276920 GRCh38: Ensembl release 89: ENSG00000145506, ENSG00000276920 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021567 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wharton KA, Zimmermann G, Rousset R, Scott MP (June 2001). "Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling". Developmental Biology. 234 (1): 93–106. doi:10.1006/dbio.2001.0238. PMID 11356022. S2CID 18903944.
↑ Katoh M (November 2001). "Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2". International Journal of Oncology. 19 (5): 963–969. doi:10.3892/ijo.19.5.963. PMID 11604995.
↑ Li C, Franklin JL, Graves-Deal R, Jerome WG, Cao Z, Coffey RJ (April 2004). "Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (15): 5571–5576. Bibcode:2004PNAS..101.5571L. doi:10.1073/pnas.0401294101. PMC 397424. PMID 15064403.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000276920 GRCh38: Ensembl release 89: ENSG00000145506, ENSG00000276920 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021567 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Wharton KA, Zimmermann G, Rousset R, Scott MP (June 2001). "Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling". Developmental Biology. 234 (1): 93–106. doi:10.1006/dbio.2001.0238. PMID 11356022. S2CID 18903944.

[6] Katoh M (November 2001). "Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2". International Journal of Oncology. 19 (5): 963–969. doi:10.3892/ijo.19.5.963. PMID 11604995.

[7] Li C, Franklin JL, Graves-Deal R, Jerome WG, Cao Z, Coffey RJ (April 2004). "Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (15): 5571–5576. Bibcode:2004PNAS..101.5571L. doi:10.1073/pnas.0401294101. PMC 397424. PMID 15064403.