NKIRAS2

NKIRAS2
Identifiers
Aliases	NKIRAS2, KBRAS2, kappaB-Ras2, NFKB inhibitor interacting Ras like 2
External IDs	OMIM: 604497; MGI: 1919216; GeneCards: NKIRAS2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,025,644 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,518,433 bp
RNA expression pattern
	Top expressed in
	monocyte; ; ganglionic eminence; ; stromal cell of endometrium; ; gastrocnemius muscle; ; left ventricle; ; apex of heart; ; muscle of thigh; ; granulocyte; ; right auricle of heart; ; popliteal artery;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; granulocyte; ; lip; ; medial ganglionic eminence; ; right ventricle; ; neural tube; ; cornea; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; GTPase activity;
Cellular component	cytoplasm; membrane; cellular component;
Biological process	I-kappaB kinase/NF-kappaB signaling; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	28511
	71966
	ENSG00000168256
	ENSMUSG00000017837
	Q9NYR9
	Q9CR56
	NM_001001349; NM_001144927; NM_001144928; NM_001144929; NM_017595
	NM_028024
NP_001001349; NP_001138399; NP_001138400; NP_001138401; NP_060065;
	NP_001001349.1; NP_001138399.1; NP_060065.2
	NP_082300
	Wikidata
View/Edit Human	View/Edit Mouse

NF-κB inhibitor interacting Ras-like 2 is a protein that in humans is encoded by the NKIRAS2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168256 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017837 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: NFKB inhibitor interacting Ras-like 2". Retrieved 2011-08-30.

Tago K, Funakoshi-Tago M, Sakinawa M, Mizuno N, Itoh H (Oct 2010). "KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA". The Journal of Biological Chemistry. 285 (40): 30622–33. doi:10.1074/jbc.M110.117028. PMC 2945557. PMID 20639196.
Fenwick C, Na SY, Voll RE, Zhong H, Im SY, Lee JW, Ghosh S (Feb 2000). "A subclass of Ras proteins that regulate the degradation of IkappaB". Science. 287 (5454): 869–73. Bibcode:2000Sci...287..869F. doi:10.1126/science.287.5454.869. PMID 10657303.
Dieguez-Gonzalez R, Akar S, Calaza M, Perez-Pampin E, Costas J, Torres M, Vicario JL, Velloso ML, Navarro F, Narvaez J, Joven B, Herrero-Beaumont G, Gonzalez-Alvaro I, Fernandez-Gutierrez B, de la Serna AR, Carreño L, Lopez-Longo J, Caliz R, Collado-Escobar MD, Blanco FJ, Fernandez-Lopez C, Balsa A, Pascual-Salcedo D, Gomez-Reino JJ, Gonzalez A (Apr 2009). "Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis". Annals of the Rheumatic Diseases. 68 (4): 579–83. doi:10.1136/ard.2007.087304. PMID 18434448. S2CID 24874869.

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