NOX3

NOX3
Identifiers
Aliases	NOX3, GP91-3, MOX-2, NADPH oxidase 3
External IDs	OMIM: 607105; MGI: 2681162; GeneCards: NOX3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	155,455,839 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	3,746,536 bp
RNA expression pattern
	Top expressed in
	Cortex of frontal lobe; ; hippocampus proper; ; right frontal lobe;
	Top expressed in
	spermatid; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; superoxide-generating NAD(P)H oxidase activity;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; NADPH oxidase complex; extracellular exosome; membrane;
Biological process	response to gravity; temperature homeostasis; detection of gravity; otolith development; superoxide anion generation; defense response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	50508
	224480
	ENSG00000074771
	ENSMUSG00000023802
	Q9HBY0
	Q672J9
	NM_015718
	NM_198958
	NP_056533
	NP_945196
	Wikidata
View/Edit Human	View/Edit Mouse

NADPH oxidase 3 is an enzyme that in humans is encoded by the NOX3 gene.

Function

NADPH oxidases, such as NOX3, are plasma membrane-associated enzymes found in many cell types. They catalyze the production of superoxide by a one-electron reduction of oxygen, using NADPH as the electron donor.[supplied by OMIM]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000074771 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023802 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Herb M (February 2024). "NADPH oxidase 3: Beyond the innear ear". Antioxidants. 13 (2): 219. doi:10.3390/antiox13020219. PMC 10886416. PMID 38397817.
↑ Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD (May 2001). "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5". Gene. 269 (1–2): 131–40. doi:10.1016/S0378-1119(01)00449-8. PMID 11376945.
1 2 "Entrez Gene: NOX3 NADPH oxidase 3".

Lachgar A, Sojic N, Arbault S, Bruce D, Sarasin A, Amatore C, Bizzini B, Zagury D, Vuillaume M (1999). "Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins". J. Virol. 73 (2): 1447–52. doi:10.1128/JVI.73.2.1447-1452.1999. PMC 103969. PMID 9882350.
Kikuchi H, Hikage M, Miyashita H, Fukumoto M (2000). "NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells". Gene. 254 (1–2): 237–43. doi:10.1016/S0378-1119(00)00258-4. PMID 10974555.
Cheng G, Ritsick D, Lambeth JD (2004). "Nox3 regulation by NOXO1, p47phox, and p67phox". J. Biol. Chem. 279 (33): 34250–5. doi:10.1074/jbc.M400660200. PMID 15181005.
Jana A, Pahan K (2004). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". J. Neurosci. 24 (43): 9531–40. doi:10.1523/JNEUROSCI.3085-04.2004. PMC 1955476. PMID 15509740.
Ueno N, Takeya R, Miyano K, Kikuchi H, Sumimoto H (2005). "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators". J. Biol. Chem. 280 (24): 23328–39. doi:10.1074/jbc.M414548200. PMID 15824103.
Ueyama T, Geiszt M, Leto TL (2006). "Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases" (PDF). Mol. Cell. Biol. 26 (6): 2160–74. doi:10.1128/MCB.26.6.2160-2174.2006. PMC 1430270. PMID 16507994. Archived from the original (PDF) on 2020-10-09. Retrieved 2018-11-04.
Carnesecchi S, Carpentier JL, Foti M, Szanto I (2006). "Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3". Exp. Cell Res. 312 (17): 3413–24. doi:10.1016/j.yexcr.2006.07.003. PMID 16949073.
Nakano Y, Banfi B, Jesaitis AJ, Dinauer MC, Allen LA, Nauseef WM (2007). "Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3". Biochem. J. 403 (1): 97–108. doi:10.1042/BJ20060819. PMC 1828898. PMID 17140397.
Chen G, Adeyemo AA, Zhou J, Chen Y, Doumatey A, Lashley K, Huang H, Amoah A, Agyenim-Boateng K, Eghan BA, Okafor G, Acheampong J, Oli J, Fasanmade O, Johnson T, Rotimi C (2007). "A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes". Am. J. Kidney Dis. 49 (3): 394–400. doi:10.1053/j.ajkd.2006.12.011. PMID 17336700.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000074771 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023802 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Herb M (February 2024). "NADPH oxidase 3: Beyond the innear ear". Antioxidants. 13 (2): 219. doi:10.3390/antiox13020219. PMC 10886416. PMID 38397817.

[pmid11376945-6] Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD (May 2001). "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5". Gene. 269 (1–2): 131–40. doi:10.1016/S0378-1119(01)00449-8. PMID 11376945.

[entrez-7] 1 2 "Entrez Gene: NOX3 NADPH oxidase 3".

NOX3

Function

References

Further reading