Nucleoplasmin-3

NPM3
Identifiers
Aliases	NPM3, PORMIN, TMEM123, nucleophosmin/nucleoplasmin 3
External IDs	OMIM: 606456; MGI: 894653; GeneCards: NPM3
Gene location (Human)
Chr.	Chromosome 10 (human)
End	101,783,413 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	45,738,030 bp
RNA expression pattern
	Top expressed in
	oocyte; ; stromal cell of endometrium; ; secondary oocyte; ; gonad; ; body of pancreas; ; mucosa of transverse colon; ; islet of Langerhans; ; left adrenal cortex; ; right adrenal gland; ; right adrenal cortex;
	Top expressed in
	epiblast; ; spermatocyte; ; thymus; ; embryo; ; yolk sac; ; testicle; ; lens; ; ileum; ; spermatid; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; chromatin binding; histone binding;
Cellular component	nucleus; nucleolus; cytosol; actin cytoskeleton; nucleoplasm; cytoplasm;
Biological process	rRNA processing; rRNA transcription; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10360
	18150
	ENSG00000107833
	ENSMUSG00000056209
	O75607
	Q9CPP0
	NM_006993
	NM_008723
	NP_008924
	NP_032749
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoplasmin-3 is a protein that in humans is encoded by the NPM3 gene. This protein is involved in the regulation of many different cellular process including ribosome biogenesis, chromatin remodeling, and protein chaperoning. As part of this, 4 copies of this protein bind to 1 copy of nucleophosmin to form an efficient chromatin remodeling protein complex.

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. Based on the structural similarity of the human NPM3 gene product to nucleoplasmin and nucleophosmin, NPM3 may share basic functions with the molecular chaperones.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107833 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056209 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shackleford GM, Ganguly A, MacArthur CA (Jul 2003). "Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones". BMC Genomics. 2: 8. doi:10.1186/1471-2164-2-8. PMC 60000. PMID 11722795.
1 2 "Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3".
1 2 "Nucleoplasmin-3". UniProt consortium. Retrieved 2026-10-08.

External links

NPM3 human gene location in the UCSC Genome Browser.
NPM3 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107833 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056209 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11722795-5] Shackleford GM, Ganguly A, MacArthur CA (Jul 2003). "Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones". BMC Genomics. 2: 8. doi:10.1186/1471-2164-2-8. PMC 60000. PMID 11722795.

[entrez-6] 1 2 "Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3".

[uniprot-7] 1 2 "Nucleoplasmin-3". UniProt consortium. Retrieved 2026-10-08.

Nucleoplasmin-3

References

Further reading

External links