NPW

NPW

Identifiers

NPW, L8, L8C, PPL8, PPneuropeptide W

External IDs

OMIM: 607997; MGI: 2685781; GeneCards: NPW

Gene location (Human)

Chr.	Chromosome 16 (human)

Band	16p13.3	Start	2,009,926 bp
Band	16p13.3	End	2,020,755 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 A3.3	Start	24,876,304 bp
Band	17\|17 A3.3	End	24,877,431 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

testicle

decidua

right lobe of liver

gonad

stromal cell of endometrium

pituitary gland

anterior pituitary

olfactory zone of nasal mucosa

skin of abdomen

skin of leg

Top expressed in

embryo

lung

embryo

morula

epiblast

stomach

uterus

pancreas

spleen

superior frontal gyrus

More reference expression data

n/a

Gene ontology
Molecular function	protein binding G protein-coupled receptor binding
Cellular component	extracellular region
Biological process	neuropeptide signaling pathway feeding behavior G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


283869


381073


ENSG00000183971


ENSMUSG00000071230


Q8N729


Q3V2F0

RefSeq (mRNA)


NM_001099456


NM_001099664

RefSeq (protein)


NP_001092926


NP_001093134

Location (UCSC)

Chr 16: 2.01 – 2.02 Mb

Chr 17: 24.88 – 24.88 Mb

PubMed search

View/Edit Human

View/Edit Mouse

NPW is a gene that in humans encodes Neuropeptide W protein.

Neuropeptide W (NPW) is an endogenous peptide ligand for GPR8 (MIM 600731), a G protein-coupled receptor.[supplied by OMIM]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183971 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071230 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M (Sep 2002). "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7". J Biol Chem. 277 (37): 34010–6. doi:10.1074/jbc.M205883200. PMID 12118011.
↑ Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M (Jan 2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J Biol Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
1 2 "Entrez Gene: NPW neuropeptide W".

Further reading

Singh G, Davenport AP (2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". Br. J. Pharmacol. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. Bibcode:2003PNAS..100.6251T. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
Mondal MS, Yamaguchi H, Date Y, et al. (2003). "A role for neuropeptide W in the regulation of feeding behavior". Endocrinology. 144 (11): 4729–33. doi:10.1210/en.2003-0536. PMID 12959997.
Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.
Andreis PG, Rucinski M, Neri G, et al. (2006). "Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects". Int. J. Mol. Med. 16 (6): 1021–8. doi:10.3892/ijmm.16.6.1021. PMID 16273281.
Mondal MS, Yamaguchi H, Date Y, et al. (2006). "Neuropeptide W is present in antral G cells of rat, mouse, and human stomach". J. Endocrinol. 188 (1): 49–57. doi:10.1677/joe.1.06195. PMID 16394174.

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