NUTF2

NUTF2
Identifiers
Aliases	NUTF2, NTF2, PP15, NTF-2, nuclear transport factor 2
External IDs	OMIM: 605813; MGI: 3704482; GeneCards: NUTF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GY5,%%s1GY6, 5BXQ, 1A2K, 1OUN
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,872,567 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; ascending aorta; ; popliteal artery; ; tibial arteries; ; left coronary artery; ; C1 segment; ; Descending thoracic aorta; ; right coronary artery; ; anterior cingulate cortex; ; stromal cell of endometrium;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; structural constituent of nuclear pore; identical protein binding; nuclear import signal receptor activity;
Cellular component	cytoplasm; nuclear pore central transport channel; nuclear outer membrane; intracellular anatomical structure; extracellular exosome; nucleus; nuclear inner membrane; nuclear pore; nucleoplasm; cytosol; membrane; nuclear membrane;
Biological process	negative regulation of vascular endothelial growth factor production; protein transport; positive regulation of protein import into nucleus; protein export from nucleus; protein import into nucleus; mRNA transport; protein localization to nuclear pore; transport; nucleocytoplasmic transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10204
	621832
	ENSG00000102898
	n/a
	P61970
	P61971
	NM_005796; NM_001322038; NM_001322039; NM_001322040; NM_001322041
	XM_001473957
NP_001308967; NP_001308968; NP_001308969; NP_001308970; NP_005787;
	NP_005787.1; NP_001308967.1; NP_001308968.1; NP_001308969.1; NP_001308970.1
	NP_080808; NP_001344158; NP_001344159
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear transport factor 2 is a protein that in humans is encoded by the NUTF2 gene.

Function

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.