NUDCD3

NUDCD3
Identifiers
Aliases	NUDCD3, NudCL, NudC domain containing 3
External IDs	OMIM: 610296; MGI: 2144158; GeneCards: NUDCD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGV
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,490,658 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,150,415 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; gastrocnemius muscle; ; stromal cell of endometrium; ; nucleus accumbens; ; islet of Langerhans; ; muscle of thigh;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; primary visual cortex; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; cerebellar cortex; ; piriform cortex; ; temporal muscle; ; subiculum; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; unfolded protein binding;
Cellular component	cytoplasm; cytoplasmic dynein complex;
Biological process	protein folding; cilium assembly; protein localization to pericentriolar material; developmental process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23386
	209586
	ENSG00000015676
	ENSMUSG00000053838
	Q8IVD9
	Q8R1N4
	NM_015332
	NM_173748; NM_001363446
	NP_056147
	NP_776109; NP_001350375
	Wikidata
View/Edit Human	View/Edit Mouse

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.

Function

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000015676 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053838 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: NUDCD3 NudC domain containing 3".

Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, et al. (June 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zhou T, Zimmerman W, Liu X, Erikson RL (2006). "A mammalian NudC-like protein essential for dynein stability and cell viability". Proceedings of the National Academy of Sciences of the United States of America. 103 (24): 9039–9044. Bibcode:2006PNAS..103.9039Z. doi:10.1073/pnas.0602916103. PMC 1482562. PMID 16754861.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000015676 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: NUDCD3 NudC domain containing 3".

NUDCD3

Function

References

Further reading