NUDT9

NUDT9

Identifiers

NUDT9, NUDT10, nudix hydrolase 9

External IDs

OMIM: 606022; MGI: 1921417; GeneCards: NUDT9

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1Q33, 1QVJ

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
3.6.1.13	↗	↗	↗	↗

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 E5	Start	104,194,172 bp
Band	5\|5 E5	End	104,213,245 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

islet of Langerhans

body of pancreas

middle temporal gyrus

duodenum

parotid gland

right adrenal gland

rectum

jejunal mucosa

left adrenal gland

glomerulus

Top expressed in

saccule

otic placode

otic vesicle

vestibular membrane of cochlear duct

seminiferous tubule

fetal liver hematopoietic progenitor cell

sciatic nerve

interventricular septum

extensor digitorum longus muscle

plantaris muscle

More reference expression data


More reference expression data

Gene ontology
Molecular function	hydrolase activity ADP-ribose diphosphatase activity ADP-sugar diphosphatase activity adenosine-diphosphatase activity
Cellular component	mitochondrial matrix intracellular anatomical structure extracellular exosome mitochondrion cell junction nuclear membrane
Biological process	nucleobase-containing small molecule catabolic process IDP catabolic process ADP catabolic process
Sources:Amigo / QuickGO

Databases

Species

Human

Mouse


53343


74167


n/a


ENSMUSG00000029310


Q9BW91


Q8BVU5

RefSeq (mRNA)


NM_001248011 NM_024047 NM_198038


NM_028794

RefSeq (protein)


NP_001234940 NP_076952 NP_932155


NP_083070

Location (UCSC)

n/a

Chr 5: 104.19 – 104.21 Mb

PubMed search

View/Edit Human

View/Edit Mouse

ADP-ribose pyrophosphatase, mitochondrial is an enzyme that in humans is encoded by the NUDT9 gene.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029310 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (May 2001). "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology". Nature. 411 (6837): 595–9. Bibcode:2001Natur.411..595P. doi:10.1038/35079100. PMID 11385575. S2CID 4338852.
↑ Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM (Jan 2003). "NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase". J Biol Chem. 278 (3): 1794–801. doi:10.1074/jbc.M205601200. PMID 12427752.
↑ "Entrez Gene: NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9".

Further reading

Lin S, Gasmi L, Xie Y, et al. (2002). "Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose)". Biochim. Biophys. Acta. 1594 (1): 127–35. doi:10.1016/S0167-4838(01)00296-5. PMID 11825615.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang HT, Yan ZQ, Hu XB, et al. (2004). "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 35 (8): 747–51. PMID 12897971.
Shen BW, Perraud AL, Scharenberg A, Stoddard BL (2003). "The crystal structure and mutational analysis of human NUDT9". J. Mol. Biol. 332 (2): 385–98. doi:10.1016/S0022-2836(03)00954-9. PMID 12948489.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Carloto A, Costas MJ, Cameselle JC, et al. (2006). "The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2". Biochim. Biophys. Acta. 1760 (10): 1545–51. doi:10.1016/j.bbagen.2006.06.003. PMID 16860484.

v t e PDB gallery
1q33: Crystal structure of human ADP-ribose pyrophosphatase NUDT9 1qvj: structure of NUDT9 complexed with ribose-5-phosphate

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