Nucleoporin NUP42

NUP42
Identifiers
Aliases	NUP42, CG1, NLP-1, NLP_1, hCG1, nucleoporin like 2, NUPL2, nucleoporin 42
External IDs	MGI: 2387631; GeneCards: NUP42
Gene location (Human)
Chr.	Chromosome 7 (human)
End	23,201,011 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,389,011 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; monocyte; ; right hemisphere of cerebellum; ; rectum; ; right uterine tube; ; right testis; ; left testis; ; right adrenal cortex; ; gonad; ; spleen;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; interventricular septum; ; internal carotid artery; ; external carotid artery; ; embryo; ; muscle of thigh; ; embryo; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nuclear export signal receptor activity; metal ion binding; protein binding; RNA binding;
Cellular component	nuclear membrane; nuclear envelope; membrane; nuclear pore; nucleoplasm; nucleus; cytosol; host cell;
Biological process	mRNA transport; viral transcription; protein sumoylation; mitotic nuclear membrane disassembly; protein export from nucleus; regulation of cellular response to heat; protein transport; viral process; intracellular transport of virus; mRNA export from nucleus; tRNA export from nucleus; regulation of gene silencing by miRNA; regulation of glycolytic process; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11097
	231042
	ENSG00000136243
	ENSMUSG00000048439
	O15504
	Q8CIC2
	NM_007342; NM_001370443; NM_001370444; NM_001370445; NM_001370446
	NM_153092; NM_001346582
	NP_031368; NP_001357372; NP_001357373; NP_001357374; NP_001357375
	NP_001333511; NP_694732
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin NUP42 is a protein that in humans is encoded by the NUP42 gene (previously NUPL2). This protein is involved in the transporting of mRNA (with poly(A) tails) out of the cell nucleus and into the cytoplasm.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136243 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048439 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Farjot G, Sergeant A, Mikaelian I (Jul 1999). "A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1". J Biol Chem. 274 (24): 17309–17317. doi:10.1074/jbc.274.24.17309. PMID 10358091.
↑ Van Laer L, Van Camp G, van Zuijlen D, Green ED, Verstreken M, Schatteman I, Van de Heyning P, Balemans W, Coucke P, Greinwald JH, Smith RJ, Huizing E, Willems P (Mar 1998). "Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea". Eur J Hum Genet. 5 (6): 397–405. PMID 9450185.
↑ "Entrez Gene: NUPL2 nucleoporin like 2".
↑ "Nucleoporin NUP42". uniprot.org. UniProt consortium. Retrieved 2026-09-12.

Fouchier RA, Meyer BE, Simon JH, et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex". J. Virol. 72 (7): 6004–13. doi:10.1128/JVI.72.7.6004-6013.1998. PMC 110405. PMID 9621063.
Katahira J, Strässer K, Podtelejnikov A, et al. (1999). "The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human". EMBO J. 18 (9): 2593–2609. doi:10.1093/emboj/18.9.2593. PMC 1171339. PMID 10228171.
Strahm Y, Fahrenkrog B, Zenklusen D, et al. (1999). "The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p". EMBO J. 18 (20): 5761–5777. doi:10.1093/emboj/18.20.5761. PMC 1171643. PMID 10610322.
de Noronha CM, Sherman MP, Lin HW, et al. (2001). "Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr". Science. 294 (5544): 1105–1108. Bibcode:2001Sci...294.1105D. doi:10.1126/science.1063957. PMID 11691994. S2CID 29771914.
Le Rouzic E, Mousnier A, Rustum C, et al. (2003). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–45098. doi:10.1074/jbc.M207439200. PMID 12228227.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sasaki M, Takeda E, Takano K, et al. (2005). "Molecular cloning and functional characterization of mouse Nxf family gene products". Genomics. 85 (5): 641–653. doi:10.1016/j.ygeno.2005.01.003. PMID 15820316.
Kendirgi F, Rexer DJ, Alcázar-Román AR, et al. (2006). "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA". Mol. Biol. Cell. 16 (9): 4304–4315. doi:10.1091/mbc.E04-11-0998. PMC 1196339. PMID 16000379.
Deniaud A, Brenner C, Kroemer G (2005). "Mitochondrial membrane permeabilization by HIV-1 Vpr". Mitochondrion. 4 (2–3): 223–233. doi:10.1016/j.mito.2004.06.012. PMID 16120388.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136243 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048439 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10358091-5] Farjot G, Sergeant A, Mikaelian I (Jul 1999). "A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1". J Biol Chem. 274 (24): 17309–17317. doi:10.1074/jbc.274.24.17309. PMID 10358091.

[pmid9450185-6] Van Laer L, Van Camp G, van Zuijlen D, Green ED, Verstreken M, Schatteman I, Van de Heyning P, Balemans W, Coucke P, Greinwald JH, Smith RJ, Huizing E, Willems P (Mar 1998). "Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea". Eur J Hum Genet. 5 (6): 397–405. PMID 9450185.

[entrez-7] "Entrez Gene: NUPL2 nucleoporin like 2".

[8] "Nucleoporin NUP42". uniprot.org. UniProt consortium. Retrieved 2026-09-12.

Nucleoporin NUP42

References

Further reading