NWD1

NWD1
Identifiers
Aliases	NWD1, NACHT and WD repeat domain containing 1
External IDs	OMIM: 616250; MGI: 2442268; GeneCards: NWD1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	16,817,963 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	72,717,876 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; right uterine tube; ; corpus callosum; ; caudate nucleus; ; nucleus accumbens; ; temporal lobe; ; amygdala; ; putamen; ; anterior cingulate cortex; ; right frontal lobe;
	Top expressed in
	olfactory epithelium; ; Epithelium of choroid plexus; ; lumbar subsegment of spinal cord; ; substantia nigra; ; dentate gyrus of hippocampal formation granule cell; ; Rostral migratory stream; ; primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; nucleotide binding; RNA binding;
Cellular component	cytoplasm; cytosol; U5 snRNP; precatalytic spliceosome; catalytic step 2 spliceosome;
Biological process	RNA splicing; positive regulation of gene expression; negative regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	284434
	319555
	ENSG00000188039
	ENSMUSG00000048148
	Q149M9
	A6H603
	NM_001007525; NM_001290355; NM_001347994
	NM_001159403; NM_176940
	NP_001007526; NP_001277284; NP_001334923
	NP_795914
	Wikidata
View/Edit Human	View/Edit Mouse

NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species. The NWD1 gene of humans is located on chromosome 19. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188039 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048148 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Stein C, Caccamo M, Laird G, Leptin M (2007). "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish". Genome Biol. 8 (11) R251. doi:10.1186/gb-2007-8-11-r251. PMC 2258186. PMID 18039395.
↑ Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC (2014). "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling". Oncotarget. 5 (6): 1657–1665. doi:10.18632/oncotarget.1850. PMC 4039239. PMID 24681825.

Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Correa RG, Ware CF, Reed JC (2014). "NLRs: Sentinels of innate immunity or cancer culprits?". Oncoscience. 1 (5): 308–9. doi:10.18632/oncoscience.44. PMC 4278305. PMID 25594025.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000188039 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048148 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18039395-5] Stein C, Caccamo M, Laird G, Leptin M (2007). "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish". Genome Biol. 8 (11) R251. doi:10.1186/gb-2007-8-11-r251. PMC 2258186. PMID 18039395.

[6] Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC (2014). "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling". Oncotarget. 5 (6): 1657–1665. doi:10.18632/oncotarget.1850. PMC 4039239. PMID 24681825.

NWD1

References

Further reading