NatB acetyltransferase

NatB acetyltransferase is an enzyme in the Saccharomyces cerevisiae that functions to catalyze the dehydration synthesis of the addition of an acetyl group onto a nascent polypeptide. A list of 18 proteins are known to be acetylated by this enzyme. The subclasses of proteins with abundances of the amino acids aspartic acid, methionine specifically are acetylated.

References

↑ Helbig, Andreas O.; Rosati, Sara; Pijnappel, Pim WWM; van Breukelen, Bas; Timmers, Marc HTH; Mohammed, Shabaz; Slijper, Monique; Heck, Albert JR (2010-12-02). "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels". BMC Genomics. 11 (1): 685. doi:10.1186/1471-2164-11-685. ISSN 1471-2164. PMC 3091791. PMID 21126336.
↑ McTiernan, Nina; Kjosås, Ine; Arnesen, Thomas (2025-01-15). "Illuminating the impact of N-terminal acetylation: from protein to physiology". Nature Communications. 16 (1): 703. Bibcode:2025NatCo..16..703M. doi:10.1038/s41467-025-55960-5. ISSN 2041-1723. PMC 11735805. PMID 39814713.
↑ Van Damme, Petra; Lasa, Marta; Polevoda, Bogdan; Gazquez, Cristina; Elosegui-Artola, Alberto; Kim, Duk Soo; De Juan-Pardo, Elena; Demeyer, Kimberly; Hole, Kristine; Larrea, Esther; Timmerman, Evy; Prieto, Jesus; Arnesen, Thomas; Sherman, Fred; Gevaert, Kris (2012-07-31). "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB". Proceedings of the National Academy of Sciences. 109 (31): 12449–12454. Bibcode:2012PNAS..10912449V. doi:10.1073/pnas.1210303109. PMC 3412031. PMID 22814378.

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[1] Helbig, Andreas O.; Rosati, Sara; Pijnappel, Pim WWM; van Breukelen, Bas; Timmers, Marc HTH; Mohammed, Shabaz; Slijper, Monique; Heck, Albert JR (2010-12-02). "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels". BMC Genomics. 11 (1): 685. doi:10.1186/1471-2164-11-685. ISSN 1471-2164. PMC 3091791. PMID 21126336.

[2] McTiernan, Nina; Kjosås, Ine; Arnesen, Thomas (2025-01-15). "Illuminating the impact of N-terminal acetylation: from protein to physiology". Nature Communications. 16 (1): 703. Bibcode:2025NatCo..16..703M. doi:10.1038/s41467-025-55960-5. ISSN 2041-1723. PMC 11735805. PMID 39814713.

[3] Van Damme, Petra; Lasa, Marta; Polevoda, Bogdan; Gazquez, Cristina; Elosegui-Artola, Alberto; Kim, Duk Soo; De Juan-Pardo, Elena; Demeyer, Kimberly; Hole, Kristine; Larrea, Esther; Timmerman, Evy; Prieto, Jesus; Arnesen, Thomas; Sherman, Fred; Gevaert, Kris (2012-07-31). "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB". Proceedings of the National Academy of Sciences. 109 (31): 12449–12454. Bibcode:2012PNAS..10912449V. doi:10.1073/pnas.1210303109. PMC 3412031. PMID 22814378.