Hirschberg was born in Cincinnati, Ohio, the daughter of Sylvan Hirschberg and Alma M. Yondorf Hirschberg. Her father owned a cigar factory. She had two sisters; her sister Kate Hirschberg Kohn was a medical doctor and rehabilitation specialist.
Hirschberg was a bacteriologist at a hospital in Illinois after college. She moved to Raleigh in 1942 with the United States Public Health Service, and was affiliated with the North Carolina State Laboratory of Hygiene, later the North Carolina Department of Health, from 1945 to 1963. She taught biology at North Carolina Central University from 1963 until her retirement in 1976. She directed NCCU's summer microbiology institute for college teachers. In 1978 she was presented with the Smith College Medal.
From 1970 to 1976 Hirschberg was a member of the board of directors of the North Carolina branch of the American Civil Liberties Union (ACLU). In 1987 she was honored by the ACLU's Wake Forest chapter for her civil rights work. She wrote music reviews for the Raleigh News and Observer, and endowed a chair in the North Carolina Symphony.
"Complement Fixation Test in Carcinoma" (1933, with William Saphir)
"Complement-Fixation and Opsonification Tests of Smooth and Rough Tubercle Bacilli with the Serum of Patients Suffering from Different Grades of Tuberculosis" (1935, with Ruth Tunnicliff and Katharine M. Howell)
"The Effect of Human Tissue Juices on Tubercle Bacilli" (1938, with Lloyd Arnold)
"Laboratory Services in the Diagnosis of Leptospirosis" (1956, with Lynn Maddry and Martin Hines)
"Direct Performance and Darkfield Readings of Leptospira Tests in Plastic Trays with Depressions" (1958)
"An Investigation of Possible Wild Animal Hosts of Leptospires in the Area of the 'Fort Bragg Fever' Outbreaks" (1959, with Mildred M. Galton, Robert W. Menges, Martin P. Hines, and Robert Haberman)
"Simplified Method for Staining Smears for Fluorescent Antibody" (1962)
"Standardization of Milk Plating Media" (1963, with Thomas Bartram, Lewis J. Crally, Alfred Evans, Tom S. Gable, Ralph B. Hogan, and Howard L. Bodily)
Personal life and legacy
Hirschberg lived and traveled for many years with Geraldine Cate, an activist, educator, and musician. Their 1949 house in Raleigh was designed by modernist architect Fred Carter Williams. Hirschberg died in 1988, in Raleigh, at the age of 81. There is a collection of her papers at Smith College. and she donated art to the North Carolina Museum of Art.
12Hirschberg, Nell, and I. P. Bronstein. "Note on a Cretin's Response to Typhoid Inoculation" American Journal of the Medical Sciences 202(3)(September 1941): 333–36.
12Hirschberg, N. "Phagocytic Activity in Leukemia" American Journal of the Medical Sciences 197(5)(1939): 706–712.