NEO1

NEO1
Identifiers
Aliases	NEO1, IGDCC2, NGN, NTN1R2, neogenin 1
External IDs	OMIM: 601907; MGI: 1097159; GeneCards: NEO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X5F, 1X5G, 1X5H, 1X5I, 1X5J, 1X5K, 3P4L, 4UI2
Gene location (Human)
Chr.	Chromosome 15 (human)
End	73,305,205 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	58,943,724 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; rectum; ; epithelium of colon; ; subthalamic nucleus; ; corpus callosum; ; ventral tegmental area; ; superior vestibular nucleus; ; pylorus;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; epithelium of lens; ; renal corpuscle; ; medullary collecting duct; ; substantia nigra; ; ciliary body; ; ascending aorta; ; Rostral migratory stream; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	co-receptor binding; protein binding; signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane protein complex; plasma membrane; Golgi apparatus; integral component of plasma membrane; membrane; nucleoplasm;
Biological process	positive regulation of BMP signaling pathway; iron ion homeostasis; cell adhesion; nervous system development; axon guidance; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4756
	18007
	ENSG00000067141
	ENSMUSG00000032340
	Q92859
	P97798
	NM_001172623; NM_001172624; NM_002499
	NM_001042752; NM_008684
	NP_001166094; NP_001166095; NP_002490
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Neogenin is a protein that in humans is encoded by the NEO1 gene.

Interactions

NEO1 has been shown to interact with PTK2. Also Neogenin receptor is pointed as a component of the mechanisms that determine skeletal cell fusion via RGMa (repulsive guidance molecule a) binding.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000067141 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032340 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Meyerhardt JA, Look AT, Bigner SH, Fearon ER (April 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–1136. doi:10.1038/sj.onc.1200935. PMID 9121761.
↑ "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".
↑ Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, et al. (November 2004). "Focal adhesion kinase in netrin-1 signaling". Nature Neuroscience. 7 (11): 1204–1212. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216.
↑ do Carmo Costa A, Copola AG, Carvalho E, Souza C, Nogueira JM, Silva GA, et al. (April 2021). "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway". In Vitro Cellular & Developmental Biology. Animal. 57 (4): 415–427. doi:10.1007/s11626-021-00555-9. PMID 33748906. S2CID 232311370.