Neural cell adhesion molecule 2

NCAM2
Identifiers
Aliases	NCAM2, NCAM21, neural cell adhesion molecule 2
External IDs	OMIM: 602040; MGI: 97282; GeneCards: NCAM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DOC, 2JLL, 2KBG, 2V5T, 2VAJ, 2WIM, 2XY1, 2XY2, 2XYC
Gene location (Human)
Chr.	Chromosome 21 (human)
End	21,543,329 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	81,423,716 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; sural nerve; ; prefrontal cortex; ; stromal cell of endometrium; ; gonad; ; Brodmann area 9; ; cingulate gyrus; ; testicle; ; ganglionic eminence; ; anterior cingulate cortex;
	Top expressed in
	subiculum; ; anterior amygdaloid area; ; ventromedial nucleus; ; ventral tegmental area; ; paraventricular nucleus of hypothalamus; ; olfactory tubercle; ; medial vestibular nucleus; ; mammillary body; ; habenula; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	identical protein binding;
Cellular component	integral component of membrane; axon; membrane; plasma membrane; nuclear body;
Biological process	neuron cell-cell adhesion; cell adhesion; axonal fasciculation; sensory perception of smell;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4685
	17968
	ENSG00000154654
	ENSMUSG00000022762
	O15394
	O35136
NM_004540; NM_001352591; NM_001352592; NM_001352593; NM_001352594;
	NM_001352595; NM_001352596; NM_001352597
	NM_001113208; NM_010954
NP_004531; NP_001339520; NP_001339521; NP_001339522; NP_001339523;
	NP_001339524; NP_001339525; NP_001339526
	NP_001106679; NP_035084
	Wikidata
View/Edit Human	View/Edit Mouse

Neural cell adhesion molecule 2 is a protein that in humans is encoded by the NCAM2 gene. This protein is involved in nervous system development, and the projection of neuron axons, especially in the case of olfactory axons (involved in smell).

Medical Significance

Cancer

The NCAM2 gene has been observed progressively downregulated in human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. The source suggests that NCAM2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.

Alzheimer's disease

NCAM2 is found in lower levels in hippocampal synapses of Alzheimer's disease sufferers and is found to be broken down by beta-amyloid.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000154654 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022762 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Neural cell adhesion molecule 2". uniprot.org. UniProt consortium. Retrieved 2026-10-11.
↑ Parcerisas A, Ortega-Gascó A, Pujadas L, Soriano E (2021-09-16). "The hidden side of NCAM family: NCAM2, a key cytoskeleton organization molecule regulating multiple neural functions". International Journal of Molecular Sciences. 22 (18): 10021. doi:10.3390/ijms221810021.{{cite journal}}: CS1 maint: article number as page number (link)
1 2 Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.
↑ Leshchyns'ka I, Liew HT, Shepherd C, Halliday GM, Stevens CH, Ke YD, Ittner LM, Sytnyk V (November 2015). "Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease". Nature Communications. 6 8836. Bibcode:2015NatCo...6.8836L. doi:10.1038/ncomms9836. PMC 4674770. PMID 26611261.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000154654 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022762 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] "Neural cell adhesion molecule 2". uniprot.org. UniProt consortium. Retrieved 2026-10-11.

[6] Parcerisas A, Ortega-Gascó A, Pujadas L, Soriano E (2021-09-16). "The hidden side of NCAM family: NCAM2, a key cytoskeleton organization molecule regulating multiple neural functions". International Journal of Molecular Sciences. 22 (18): 10021. doi:10.3390/ijms221810021.{{cite journal}}: CS1 maint: article number as page number (link)

[Rotondo_2015-7] 1 2 Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

[8] Leshchyns'ka I, Liew HT, Shepherd C, Halliday GM, Stevens CH, Ke YD, Ittner LM, Sytnyk V (November 2015). "Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease". Nature Communications. 6 8836. Bibcode:2015NatCo...6.8836L. doi:10.1038/ncomms9836. PMC 4674770. PMID 26611261.

Neural cell adhesion molecule 2

Medical Significance

Cancer

Alzheimer's disease

See also

References