OLA1

OLA1
Identifiers
Aliases	OLA1, DOC45, GBP45, GTBP9, GTPBP9, PTD004, Obg-like ATPase 1, Obg like ATPase 1
External IDs	OMIM: 611175; MGI: 1914309; GeneCards: OLA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OHF
Gene location (Human)
Chr.	Chromosome 2 (human)
End	174,248,599 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	73,049,268 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ganglionic eminence; ; lateral nuclear group of thalamus; ; pons; ; Brodmann area 23; ; gingival epithelium; ; lactiferous duct; ; parotid gland; ; entorhinal cortex; ; ventricular zone;
	Top expressed in
	Paneth cell; ; tail of embryo; ; cumulus cell; ; condyle; ; ureter; ; medial ganglionic eminence; ; primitive streak; ; epiblast; ; barrel cortex; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; hydrolase activity; metal ion binding; ATP binding; ATPase activity; cadherin binding; ribosome binding; ribosomal large subunit binding;
Cellular component	centrosome; nucleolus; extracellular exosome; membrane; nucleus; extracellular region; cytoplasm; cytosol; platelet alpha granule lumen;
Biological process	ATP metabolic process; platelet degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29789
	67059
	ENSG00000138430
	ENSMUSG00000027108
	Q9NTK5
	Q9CZ30
	NM_013341; NM_001011708; NM_001328688
	NM_025942; NM_030091
	NP_001011708; NP_001315617; NP_037473
	NP_080218; NP_084367
	Wikidata
View/Edit Human	View/Edit Mouse

Obg-like ATPase 1 is an enzyme that in humans is encoded by the OLA1 gene. Ola1 belongs to the protein family of Obg-like GTPases but defines an exceptional example of a protein that has evolved altered nucleotide specificity and binds adenosine triphosphate (ATP) with higher affinity than guanosine triphosphate (GTP).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138430 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027108 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Koller-Eichhorn R, Marquardt T, Gail R, Wittinghofer A, Kostrewa D, Kutay U, Kambach C (Jul 2007). "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins". J Biol Chem. 282 (27): 19928–37. doi:10.1074/jbc.M700541200. PMID 17430889.
↑ "Entrez Gene: GTPBP9 GTP-binding protein 9 (putative)".

External links

Overview of all the structural information available in the PDB for UniProt: Q9NTK5 (Obg-like ATPase 1) at the PDBe-KB.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138430 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027108 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17430889-5] 1 2 Koller-Eichhorn R, Marquardt T, Gail R, Wittinghofer A, Kostrewa D, Kutay U, Kambach C (Jul 2007). "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins". J Biol Chem. 282 (27): 19928–37. doi:10.1074/jbc.M700541200. PMID 17430889.

[entrez-6] "Entrez Gene: GTPBP9 GTP-binding protein 9 (putative)".

OLA1

References

Further reading

External links