ORM1

ORM1
Identifiers
Aliases	ORM1, AGP-A, AGP1, HEL-S-153w, ORM, orosomucoid 1
External IDs	OMIM: 138600; MGI: 97445; GeneCards: ORM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KQ0
Gene location (Human)
Chr.	Chromosome 9 (human)
End	114,326,479 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	63,277,748 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; bone marrow; ; bone marrow cell; ; blood; ; trabecular bone; ; granulocyte; ; right lung; ; right adrenal gland; ; upper lobe of left lung;
	Top expressed in
	seminal vesicula; ; granulocyte; ; embryo; ; adrenal gland; ; white adipose tissue; ; liver; ; brown adipose tissue; ; tunica adventitia of aorta; ; left lobe of liver; ; neural layer of retina;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	blood microparticle; extracellular exosome; platelet alpha granule lumen; extracellular space; specific granule lumen; tertiary granule lumen; extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; regulation of immune system process; inflammatory response; acute-phase response; platelet degranulation; neutrophil degranulation; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5004
	18407
	ENSG00000229314
	ENSMUSG00000028359
	P02763
	Q63805
	NM_000607
	NM_013623; NM_001379520; NM_001379521
	NP_000598
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.

Interactions

ORM1 has been shown to interact with Plasminogen activator inhibitor-1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000229314 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028359 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ORM1 orosomucoid 1".
↑ Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity". J. Biol. Chem. 276 (38). United States: 35305–11. doi:10.1074/jbc.M104028200. ISSN 0021-9258. PMID 11418606.

Treuheit MJ, Costello CE, Halsall HB (1992). "Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein". Biochem. J. 283 (1): 105–12. doi:10.1042/bj2830105. PMC 1131000. PMID 1567356.
Dente L, Ciliberto G, Cortese R (1985). "Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes". Nucleic Acids Res. 13 (11): 3941–52. doi:10.1093/nar/13.11.3941. PMC 341288. PMID 2409529.
Dubé JY, Paradis G, Têtu B, Tremblay RR (1989). "Synthesis of alpha 1-acid glycoprotein by the human prostate". Prostate. 15 (3): 251–8. doi:10.1002/pros.2990150305. PMID 2479939. S2CID 84445745.
Zuffardi O, Caiulo A, Maraschio P, et al. (1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?". Hum. Genet. 82 (1): 17–9. doi:10.1007/bf00288264. hdl:11380/649373. PMID 2541064. S2CID 42021177.
Dente L, Pizza MG, Metspalu A, Cortese R (1987). "Structure and expression of the genes coding for human alpha 1-acid glycoprotein". EMBO J. 6 (8): 2289–96. doi:10.1002/j.1460-2075.1987.tb02503.x. PMC 553631. PMID 2822385.
Merritt CM, Board PG (1988). "Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene". Gene. 66 (1): 97–106. doi:10.1016/0378-1119(88)90228-4. PMID 2970990.
Dente L, Rüther U, Tripodi M, et al. (1988). "Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice". Genes Dev. 2 (2): 259–66. doi:10.1101/gad.2.2.259. PMID 3360326.
Rocchi M, Roncuzzi L, Santamaria R, et al. (1986). "Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9". Hum. Genet. 74 (1): 30–3. doi:10.1007/BF00278781. PMID 3463531. S2CID 34725840.
Board PG, Jones IM, Bentley AK (1986). "Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA". Gene. 44 (1): 127–31. doi:10.1016/0378-1119(86)90051-X. PMID 3770479.
Krauss E, Polnaszek CF, Scheeler DA, et al. (1987). "Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera". J. Pharmacol. Exp. Ther. 239 (3): 754–9. PMID 3795040.
Ikenaka T, Ishiguro M, Emura J, et al. (1972). "Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment". Biochemistry. 11 (20): 3817–29. doi:10.1021/bi00770a022. PMID 4561179.
Schmid K, Bürgi W, Collins JH, Nanno S (1974). "The disulfide bonds of alpha1-acid glycoprotein". Biochemistry. 13 (13): 2694–7. doi:10.1021/bi00710a006. PMID 4603214.
Schmid K, Kaufmann H, Isemura S, et al. (1973). "Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins". Biochemistry. 12 (14): 2711–24. doi:10.1021/bi00738a026. PMID 4711474.
Mbuyi JM, Dequeker J, Bloemmen F, Stevens E (1982). "Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE". Calcif. Tissue Int. 34 (3): 229–31. doi:10.1007/BF02411242. PMID 6809283. S2CID 13305518.
Rabehi L, Ferriere F, Saffar L, Gattegno L (1995). "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans". Glycoconj. J. 12 (1): 7–16. doi:10.1007/BF00731863. PMID 7795416. S2CID 23508679.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
Nakamura T, Board PG, Matsushita K, et al. (1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis" (PDF). Inflammation. 17 (1): 33–45. doi:10.1007/BF00916390. hdl:2027.42/44509. PMID 8432561. S2CID 6012698.
Yuasa I, Umetsu K, Vogt U, et al. (1997). "Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S". Hum. Genet. 99 (3): 393–8. doi:10.1007/s004390050378. PMID 9050929. S2CID 21298011.
Morin D, Simon N, Deprés-Brummer P, et al. (1997). "Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum". Pharmacology. 54 (5): 271–5. doi:10.1159/000139495. PMID 9380773.
Nakamura H, Yuasa I, Umetsu K, et al. (2000). "The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2". Biochem. Biophys. Res. Commun. 276 (2): 779–84. doi:10.1006/bbrc.2000.3522. PMID 11027547.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000229314 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028359 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ORM1 orosomucoid 1".

[pmid11418606-6] Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity". J. Biol. Chem. 276 (38). United States: 35305–11. doi:10.1074/jbc.M104028200. ISSN 0021-9258. PMID 11418606.

ORM1

Interactions

See also

References

Further reading