OSBPL1A

OSBPL1A
Identifiers
Aliases	OSBPL1A, ORP-1, ORP1, OSBPL1B, oxysterol binding protein like 1A
External IDs	OMIM: 606730; MGI: 1927551; GeneCards: OSBPL1A
Gene location (Human)
Chr.	Chromosome 18 (human)
End	24,397,880 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	13,074,898 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; postcentral gyrus; ; external globus pallidus; ; subthalamic nucleus; ; pons; ; pars reticulata; ; lateral nuclear group of thalamus; ; occipital lobe;
	Top expressed in
	prefrontal cortex; ; deep cerebellar nuclei; ; barrel cortex; ; medial geniculate nucleus; ; primary motor cortex; ; medial dorsal nucleus; ; pontine nuclei; ; lateral geniculate nucleus; ; medial vestibular nucleus; ; olfactory epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cholesterol binding; protein binding; phospholipid binding; lipid binding; sterol transporter activity; sterol binding;
Cellular component	endosome; late endosome; intracellular anatomical structure; extracellular exosome; cytosol; membrane; intracellular membrane-bounded organelle;
Biological process	lipid transport; cholesterol metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; vesicle-mediated transport; bile acid biosynthetic process; sterol transport; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	114876
	64291
	ENSG00000141447
	ENSMUSG00000044252
	Q9BXW6
	Q91XL9
	NM_001242508; NM_018030; NM_080597; NM_133268
NM_001252489; NM_001252490; NM_001252491; NM_001252492; NM_001252493;
	NM_020573; NM_207530
	NP_001229437; NP_060500; NP_542164
NP_001239418; NP_001239419; NP_001239420; NP_001239421; NP_001239422;
	NP_997413
	Wikidata
View/Edit Human	View/Edit Mouse

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.