OSBPL3

OSBPL3
Identifiers
Aliases	OSBPL3, ORP-3, ORP3, OSBP3, oxysterol binding protein like 3
External IDs	OMIM: 606732; MGI: 1918970; GeneCards: OSBPL3
Gene location (Human)
Chr.	Chromosome 7 (human)
End	24,981,634 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	50,433,181 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; amniotic fluid; ; oocyte; ; secondary oocyte; ; left lobe of thyroid gland; ; gonad; ; right lobe of thyroid gland; ; stromal cell of endometrium; ; mucosa of paranasal sinus; ; skin of abdomen;
	Top expressed in
	transitional epithelium of urinary bladder; ; lumbar spinal ganglion; ; epithelium of stomach; ; proximal tubule; ; right kidney; ; human kidney; ; otolith organ; ; utricle; ; ascending aorta; ; adrenal gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cholesterol binding; protein binding; lipid binding; sterol transporter activity; sterol binding;
Cellular component	perinuclear endoplasmic reticulum; cell projection; cytoplasm; endoplasmic reticulum membrane; filopodium tip; nuclear membrane; endoplasmic reticulum; plasma membrane; nucleus; membrane; cytosol; intracellular membrane-bounded organelle;
Biological process	lipid transport; bile acid biosynthetic process; sterol transport; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	26031
	71720
	ENSG00000070882
	ENSMUSG00000029822
	Q9H4L5
	Q9DBS9
NM_015550; NM_145320; NM_145321; NM_145322; NM_145323;
	NM_145324
	NM_001163645; NM_027881; NM_001347213
	NP_056365; NP_663160; NP_663161; NP_663162
	NP_001157117; NP_001334142; NP_082157
	Wikidata
View/Edit Human	View/Edit Mouse

Oxysterol-binding protein-related protein 3 is a protein that in humans is encoded by the OSBPL3 gene.

Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070882 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029822 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.
1 2 "Entrez Gene: OSBPL3 oxysterol binding protein-like 3".

Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (December 1999). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". Journal of Lipid Research. 40 (12): 2204–2211. doi:10.1016/S0022-2275(20)32095-2. PMID 10588946.
Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, et al. (August 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–1213. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
Gregorio-King CC, Collier GR, McMillan JS, Waugh CM, McLeod JL, Collier FM, et al. (October 2001). "ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells". Blood. 98 (7): 2279–2281. doi:10.1182/blood.V98.7.2279. PMID 11568019.
Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (December 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–196. doi:10.1006/geno.2001.6663. PMID 11735225.
Collier FM, Gregorio-King CC, Apostolopoulos J, Walder K, Kirkland MA (January 2003). "ORP3 splice variants and their expression in human tissues and hematopoietic cells". DNA and Cell Biology. 22 (1): 1–9. doi:10.1089/104454903321112442. hdl:10536/DRO/DU:30009437. PMID 12590732.
Lehto M, Tienari J, Lehtonen S, Lehtonen E, Olkkonen VM (January 2004). "Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7". Cell and Tissue Research. 315 (1): 39–57. doi:10.1007/s00441-003-0817-y. PMID 14593528. S2CID 21298003.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–1450. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Lehto M, Hynynen R, Karjalainen K, Kuismanen E, Hyvärinen K, Olkkonen VM (November 2005). "Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants". Experimental Cell Research. 310 (2): 445–462. doi:10.1016/j.yexcr.2005.08.003. PMID 16143324.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000070882 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029822 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Ishikawa_1998-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.

[entrez-6] 1 2 "Entrez Gene: OSBPL3 oxysterol binding protein-like 3".

OSBPL3

Function

References

Further reading