P4HTM

P4HTM
Identifiers
Aliases	P4HTM, EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4, prolyl 4-hydroxylase, transmembrane, HIDEA
External IDs	OMIM: 614584; MGI: 1921693; GeneCards: P4HTM
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,007,153 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,474,866 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; bronchial epithelial cell; ; pituitary gland; ; anterior pituitary; ; prefrontal cortex; ; right frontal lobe; ; right hemisphere of cerebellum; ; Brodmann area 9; ; nucleus accumbens; ; anterior cingulate cortex;
	Top expressed in
	substantia nigra; ; nucleus accumbens; ; temporal lobe; ; facial motor nucleus; ; prefrontal cortex; ; ventromedial nucleus; ; central gray substance of midbrain; ; lateral septal nucleus; ; anterior amygdaloid area; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	2-oxoglutarate-dependent dioxygenase activity; iron ion binding; L-ascorbic acid binding; oxidoreductase activity; dioxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; calcium ion binding; procollagen-proline 4-dioxygenase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	regulation of erythrocyte differentiation; peptidyl-proline hydroxylation to 4-hydroxy-L-proline;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54681
	74443
	ENSG00000178467
	ENSMUSG00000006675
	Q9NXG6
	Q8BG58
	NM_017732; NM_177938; NM_177939
	NM_028944; NM_001357465
	NP_808807; NP_808808
	NP_083220; NP_001344394
	Wikidata
View/Edit Human	View/Edit Mouse

Prolyl 4-hydroxylase, transmembrane is a protein that in humans is encoded by the P4HTM gene.

Function

The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178467 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006675 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Prolyl 4-hydroxylase, transmembrane". Retrieved 2017-10-03.

Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hütter J, Schramm M, Flamme I (2002). "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun. 296 (2): 343–9. doi:10.1016/s0006-291x(02)00862-8. PMID 12163023.
Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J (2003). "Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor". J. Biol. Chem. 278 (33): 30772–80. doi:10.1074/jbc.M304982200. PMID 12788921.
Pekkala M, Hieta R, Bergmann U, Kivirikko KI, Wierenga RK, Myllyharju J (2004). "The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues". J. Biol. Chem. 279 (50): 52255–61. doi:10.1074/jbc.M410007200. PMID 15456751.
Hirota K, Semenza GL (2005). "Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases". Biochem. Biophys. Res. Commun. 338 (1): 610–6. doi:10.1016/j.bbrc.2005.08.193. PMID 16154531.
Iwahashi M, Muragaki Y, Ino K (2012). "Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle". Reprod. Biol. Endocrinol. 10: 111. doi:10.1186/1477-7827-10-111. PMC 3566935. PMID 23241241.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178467 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006675 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Prolyl 4-hydroxylase, transmembrane". Retrieved 2017-10-03.

P4HTM

Function

References

Further reading