PAFAH1B2

PAFAH1B2
Identifiers
Aliases	PAFAH1B2, HEL-S-303, platelet activating factor acetylhydrolase 1b catalytic subunit 2
External IDs	OMIM: 602508; MGI: 108415; GeneCards: PAFAH1B2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1VYH
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	117,176,894 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	46,012,690 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pons; ; inferior ganglion of vagus nerve; ; superior vestibular nucleus; ; trigeminal ganglion; ; pars reticulata; ; subthalamic nucleus; ; pars compacta; ; middle temporal gyrus; ; lateral nuclear group of thalamus;
	Top expressed in
	spermatid; ; spermatocyte; ; tail of embryo; ; renal corpuscle; ; genital tubercle; ; mandibular prominence; ; neural tube; ; central gray substance of midbrain; ; somite; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	1-alkyl-2-acetylglycerophosphocholine esterase activity; platelet-activating factor acetyltransferase activity; hydrolase activity; protein homodimerization activity; protein heterodimerization activity; phospholipase A2 activity; protein binding;
Cellular component	plasma membrane; nucleolus; extracellular exosome; fibrillar center; extracellular region; cytoplasm; cytosol; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	lipid catabolic process; positive regulation of macroautophagy; brain development; spermatogenesis; lipid metabolism; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5049
	18475
	ENSG00000168092
	ENSMUSG00000003131
	P68402
	Q61206
	NM_001184746; NM_001184747; NM_001184748; NM_001309431; NM_002572
	NM_008775
	NP_001171675; NP_001171676; NP_001171677; NP_001296360; NP_002563
NP_032801; NP_001344167; NP_001344168; NP_001344169; NP_001344170;
	NP_001344172; NP_001344173; NP_001344174; NP_001344175
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene.

Interactions

PAFAH1B2 has been shown to interact with PAFAH1B1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168092 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003131 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Apr 1997). "Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I)". Biochemical and Biophysical Research Communications. 233 (1): 10–3. doi:10.1006/bbrc.1997.6383. PMID 9144386.
↑ Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Jul 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics. 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.
↑ "Entrez Gene: PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa".
↑ Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.

Albrecht U, Abu-Issa R, Rätz B, Hattori M, Aoki J, Arai H, Inoue K, Eichele G (Dec 1996). "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor". Developmental Biology. 180 (2): 579–93. doi:10.1006/dbio.1996.0330. PMID 8954729.
Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.
Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS (Jul 2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib". Protein Engineering. 14 (7): 513–9. doi:10.1093/protein/14.7.513. PMID 11522926.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hasstedt SJ, Scott BT, Rosendaal FR, Callas PW, Vossen CY, Long GL, Bovill EG (Sep 2007). "Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample". Thrombosis and Haemostasis. 98 (3): 587–92. doi:10.1160/th07-02-0134. PMID 17849047. S2CID 7180897.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168092 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003131 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9144386-5] Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Apr 1997). "Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I)". Biochemical and Biophysical Research Communications. 233 (1): 10–3. doi:10.1006/bbrc.1997.6383. PMID 9144386.

[pmid9693049-6] Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Jul 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics. 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.

[entrez-7] "Entrez Gene: PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa".

[pmid10727864-8] Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.

PAFAH1B2

Interactions

See also

References

Further reading