PALS1

PALS1
Identifiers
Aliases	PALS1, membrane palmitoylated protein 5, protein associated with LIN7 1, MAGUK p55 family member, MPP5, protein associated with LIN7 1, MAGUK family member
External IDs	OMIM: 606958; MGI: 1927339; GeneCards: PALS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y76, 3UIT, 4UU5, 4UU6, 4WSI
Gene location (Human)
Chr.	Chromosome 14 (human)
End	67,336,061 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	78,887,488 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; ventricular zone; ; germinal epithelium; ; retinal pigment epithelium; ; corpus callosum; ; inferior ganglion of vagus nerve; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; amniotic fluid; ; corpus epididymis;
	Top expressed in
	zygote; ; tail of embryo; ; spermatid; ; otic placode; ; genital tubercle; ; saccule; ; secondary oocyte; ; otic vesicle; ; left lung lobe; ; epithelium of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein binding;
Cellular component	cytoplasm; membrane; bicellular tight junction; myelin sheath adaxonal region; Schmidt-Lanterman incisure; cell junction; lateral loop; extracellular exosome; endomembrane system; plasma membrane; protein-containing complex;
Biological process	establishment of epithelial cell polarity; peripheral nervous system myelin maintenance; protein localization to myelin sheath abaxonal region; myelin assembly; bicellular tight junction assembly; plasma membrane organization; morphogenesis of an epithelial sheet; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64398
	56217
	ENSG00000072415
	ENSMUSG00000021112
	Q8N3R9
	Q9JLB2
	NM_001256550; NM_022474
	NM_019579
	NP_001243479; NP_071919
	NP_062525
	Wikidata
View/Edit Human	View/Edit Mouse

Protein PALS1 is a protein that in humans is encoded by the PALS1 gene (previously MPP5).

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (eg: DLG1), ZO1-like (eg: TJP1), p55-like (eg: MPP1), and LIN2-like (eg: CASK), based on their size and the presence of additional domains. PALS1/MPP5 is a member of the p55-like MAGUK subfamily.

Interactions

The PALS1 protein has been shown to interact with INADL and FAM71D.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000072415 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021112 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.
1 2 "Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)".

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Kamberov E, Makarova O, Roh M, et al. (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J. Biol. Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Tseng TC, Marfatia SM, Bryant PJ, et al. (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim. Biophys. Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Makarova O, Roh MH, Liu CJ, et al. (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1–2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
Hurd TW, Gao L, Roh MH, et al. (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177. S2CID 25212419.
Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". J. Cell Sci. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187. S2CID 4482921.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Penkert RR, DiVittorio HM, Prehoda KE (2004). "Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex". Nat. Struct. Mol. Biol. 11 (11): 1122–7. doi:10.1038/nsmb839. PMC 2140275. PMID 15475968.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Stöhr H, Molday LL, Molday RS, et al. (2005). "Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina" (PDF). J. Comp. Neurol. 481 (1): 31–41. doi:10.1002/cne.20367. PMID 15558731. S2CID 19904556.
Feng W, Long JF, Zhang M (2005). "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins". Proc. Natl. Acad. Sci. U.S.A. 102 (19): 6861–6. Bibcode:2005PNAS..102.6861F. doi:10.1073/pnas.0409346102. PMC 1100767. PMID 15863617.
Kantardzhieva A, Gosens I, Alexeeva S, et al. (2005). "MPP5 recruits MPP4 to the CRB1 complex in photoreceptors". Invest. Ophthalmol. Vis. Sci. 46 (6): 2192–201. doi:10.1167/iovs.04-1417. PMID 15914641.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000072415 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021112 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11927608-5] 1 2 Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.

[entrez-6] 1 2 "Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)".

PALS1

Interactions

See also

References

Further reading