PAPLN

PAPLN

Identifiers

PAPLN, papilin, proteoglycan like sulfated glycoprotein, PPN

External IDs

OMIM: 617785; MGI: 2386139; GeneCards: PAPLN

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q24.2	Start	73,237,497 bp
Band	14q24.2	End	73,274,640 bp

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)

Band	12\|12 D1	Start	83,810,408 bp
Band	12\|12 D1	End	83,839,156 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tibial nerve

tendon of biceps brachii

decidua

trigeminal ganglion

spinal ganglia

gastric mucosa

sural nerve

skin of arm

left uterine tube

lymph node

Top expressed in

molar

lip

spermatocyte

esophagus

superior frontal gyrus

yolk sac

neural layer of retina

muscle of thigh

primary visual cortex

spermatid

More reference expression data

n/a

Gene ontology
Molecular function	peptidase inhibitor activity peptidase activity serine-type endopeptidase inhibitor activity
Cellular component	extracellular region
Biological process	negative regulation of peptidase activity negative regulation of endopeptidase activity proteolysis
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


89932


170721


ENSG00000100767


ENSMUSG00000021223


O95428


Q9EPX2

RefSeq (mRNA)


NM_173462 NM_001365906 NM_001365907


NM_001205343 NM_130887

RefSeq (protein)


NP_775733 NP_001352835 NP_001352836


NP_001192272 NP_570957

Location (UCSC)

Chr 14: 73.24 – 73.27 Mb

Chr 12: 83.81 – 83.84 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Papilin is a protein that in humans is encoded by the PAPLN gene. Papilin is an extracellular matrix glycoprotein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100767 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021223 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: papilin".
↑ Kramerova IA, Kawaguchi N, Fessler LI, Nelson RE, Chen Y, Kramerov AA, Kusche-Gullberg M, Kramer JM, Ackley BD, Sieron AL, Prockop DJ, Fessler JH (December 2000). "Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases". Development. 127 (24): 5475–85. doi:10.1242/dev.127.24.5475. PMID 11076767.
↑ Apte SS (November 2009). "A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms". J. Biol. Chem. 284 (46): 31493–7. doi:10.1074/jbc.R109.052340. PMC 2797218. PMID 19734141.

Further reading

Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Laje G, Allen AS, Akula N, et al. (2009). "Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients". Pharmacogenet. Genomics. 19 (9): 666–74. doi:10.1097/FPC.0b013e32832e4bcd. PMC 2819190. PMID 19724244.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.