Pappalysin-2

PAPPA2

Identifiers

PAPPA2, PAPP-A2, PAPP-E, PAPPE, PLAC3, pappalysin 2, SSDA

External IDs

MGI: 3051647; GeneCards: PAPPA2

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q25.2	Start	176,463,171 bp
Band	1q25.2	End	176,845,601 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1\|1 H1	Start	158,539,297 bp
Band	1\|1 H1	End	158,808,060 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

decidua

islet of Langerhans

cartilage tissue

ventricular zone

buccal mucosa cell

testicle

ganglionic eminence

human kidney

pancreatic ductal cell

stromal cell of endometrium

Top expressed in

calvaria

islet of Langerhans

lumbar spinal ganglion

pituitary gland

pontine nuclei

trigeminal ganglion

dermis

lobe of prostate

efferent ductule

condyle

More reference expression data

n/a

Gene ontology
Molecular function	zinc ion binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding metalloendopeptidase activity
Cellular component	extracellular region extracellular exosome intracellular anatomical structure cytosol apical plasma membrane
Biological process	bone morphogenesis regulation of cell growth proteolysis response to salt stress
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


60676


23850


ENSG00000116183


ENSMUSG00000073530


Q9BXP8


n/a

RefSeq (mRNA)


NM_020318 NM_021936


NM_001085376

RefSeq (protein)


NP_064714 NP_068755


n/a

Location (UCSC)

Chr 1: 176.46 – 176.85 Mb

Chr 1: 158.54 – 158.81 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Pappalysin-2 also known as pregnancy-associated plasma protein A2 (PAPP-A2) is a protein that in humans is encoded by the PAPPA2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116183 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073530 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (Nov 2000). "Pregnancy-associated plasma protein-E (PAPP-E)". Biochim Biophys Acta. 1493 (3): 356–62. doi:10.1016/s0167-4781(00)00195-0. PMID 11018262.
↑ Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C (Jun 2001). "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase". J Biol Chem. 276 (24): 21849–53. doi:10.1074/jbc.M102191200. PMID 11264294.
↑ "Entrez Gene: PAPPA2 pappalysin 2".

Further reading

Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant". Placenta. 22 (8–9): 681–7. doi:10.1053/plac.2001.0709. PMID 11597188.
Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900.

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