PARVB

PARVB

Identifiers

PARVB, CGI-56, parvin beta

External IDs

OMIM: 608121; MGI: 2153063; GeneCards: PARVB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4EDL, 4EDM, 4EDN

Gene location (Human)

Chr.	Chromosome 22 (human)

Band	22q13.31	Start	43,999,211 bp
Band	22q13.31	End	44,172,939 bp

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)

Band	15\|15 E2	Start	84,116,244 bp
Band	15\|15 E2	End	84,199,889 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

muscle of thigh

gastrocnemius muscle

apex of heart

monocyte

left ventricle

right auricle of heart

islet of Langerhans

right lung

right adrenal gland

upper lobe of left lung

Top expressed in

blood

lumbar spinal ganglion

muscle of thigh

molar

right lobe of liver

extraocular muscle

soleus muscle

digastric muscle

atrium

yolk sac

More reference expression data


More reference expression data

Gene ontology
Molecular function	actin binding protein binding
Cellular component	cytoplasm cytosol cell junction plasma membrane cell projection sarcomere Z discdkac cytoskeleton membrane focal adhesion lamellipodium actin cytoskeleton
Biological process	actin cytoskeleton reorganization cell adhesion cell projection assembly lamellipodium assembly establishment or maintenance of cell polarity regulating cell shape establishment or maintenance of cell polarity substrate adhesion-dependent cell spreading
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


29780


170736


ENSG00000188677


ENSMUSG00000022438


Q9HBI1


Q9ES46

RefSeq (mRNA)


NM_001003828 NM_001243385 NM_001243386 NM_013327


NM_133167

RefSeq (protein)


NP_001003828 NP_001230314 NP_001230315 NP_037459


NP_573395

Location (UCSC)

Chr 22: 44 – 44.17 Mb

Chr 15: 84.12 – 84.2 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Beta-parvin is a protein that in humans is encoded by the PARVB gene.

Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188677 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022438 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
↑ Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. doi:10.1242/jcs.114.3.525. PMID 11171322.
1 2 "Entrez Gene: PARVB parvin, beta".

Further reading

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction". J. Cell Biol. 153 (6): 1251–64. doi:10.1083/jcb.153.6.1251. PMC 2192033. PMID 11402068.
Korenbaum E, Olski TM, Noegel AA (2002). "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans". Gene. 279 (1): 69–79. doi:10.1016/S0378-1119(01)00743-0. PMID 11722847.
Yamaji S, Suzuki A, Kanamori H, et al. (2002). "Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation". Biochem. Biophys. Res. Commun. 297 (5): 1324–31. doi:10.1016/S0006-291X(02)02381-1. PMID 12372433.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol. Genet. 12 (2): 155–67. doi:10.1093/hmg/ddg019. PMID 12499396.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Mishima W, Suzuki A, Yamaji S, et al. (2004). "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor". Genes Cells. 9 (3): 193–204. doi:10.1111/j.1356-9597.2004.00717.x. PMID 15005707.
Yamaji S, Suzuki A, Kanamori H, et al. (2004). "Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction". J. Cell Biol. 165 (4): 539–51. doi:10.1083/jcb.200308141. PMC 2172344. PMID 15159419.
Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival". J. Biol. Chem. 279 (40): 41695–705. doi:10.1074/jbc.M401563200. PMID 15284246.
Mongroo PS, Johnstone CN, Naruszewicz I, et al. (2004). "Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer". Oncogene. 23 (55): 8959–70. doi:10.1038/sj.onc.1208112. PMID 15467740.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Matsuda C, Kameyama K, Tagawa K, et al. (2005). "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma". J. Neuropathol. Exp. Neurol. 64 (4): 334–40. doi:10.1093/jnen/64.4.334. PMID 15835269.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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