PASD1

PASD1
Identifiers
Aliases	PASD1, CT63, OXTES1, PAS domain containing 1, PAS domain containing repressor 1, CT64
External IDs	OMIM: 300993; GeneCards: PASD1
Gene location (Human)
Chr.	X chromosome (human)
End	151,676,739 bp
RNA expression pattern
	Top expressed in
	testicle; ; right testis; ; left testis; ; gonad; ; human musculoskeletal system; ; muscular system; ; muscle; ; skeletal muscle; ; lower limb muscles; ; muscle of leg;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator binding;
Cellular component	Cry-Per complex; nucleus; nuclear speck;
Biological process	negative regulation of circadian rhythm; negative regulation of transcription, DNA-templated; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	139135
	n/a
	ENSG00000166049
	n/a
	Q8IV76
	n/a
	NM_173493
	n/a
	NP_775764
	n/a
	Wikidata
View/Edit Human

PAS domain-containing protein 1 is a protein that in humans is encoded by the PASD1 gene.

PASD1 has been shown to inhibit the transcriptional activity between CLOCK and BMAL1 which appears to be co-opted in cancer cells to attenuate clock function.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166049 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH (July 2004). "Serologic detection of diffuse large B-cell lymphoma-associated antigens". International Journal of Cancer. 110 (4): 563–569. doi:10.1002/ijc.20170. PMID 15122589.
↑ Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH (July 2004). "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein". British Journal of Cancer. 91 (1): 141–149. doi:10.1038/sj.bjc.6601875. PMC 2364759. PMID 15162151.
↑ "Entrez Gene: PASD1 PAS domain containing 1".
↑ Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL (June 2015). "Cancer/Testis Antigen PASD1 Silences the Circadian Clock". Molecular Cell. 58 (5): 743–754. doi:10.1016/j.molcel.2015.03.031. PMC 4458219. PMID 25936801.
↑ Greenwood V (15 September 2015). "How the Body's Trillions of Clocks Keep Time". Quanta Magazine.

Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, et al. (October 2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochemical and Biophysical Research Communications. 335 (4): 1293–1304. Bibcode:2005BBRC..335.1293G. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166049 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15122589-3] Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH (July 2004). "Serologic detection of diffuse large B-cell lymphoma-associated antigens". International Journal of Cancer. 110 (4): 563–569. doi:10.1002/ijc.20170. PMID 15122589.

[pmid15162151-4] Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH (July 2004). "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein". British Journal of Cancer. 91 (1): 141–149. doi:10.1038/sj.bjc.6601875. PMC 2364759. PMID 15162151.

[entrez-5] "Entrez Gene: PASD1 PAS domain containing 1".

[6] Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL (June 2015). "Cancer/Testis Antigen PASD1 Silences the Circadian Clock". Molecular Cell. 58 (5): 743–754. doi:10.1016/j.molcel.2015.03.031. PMC 4458219. PMID 25936801.

[7] Greenwood V (15 September 2015). "How the Body's Trillions of Clocks Keep Time". Quanta Magazine.

PASD1

References

Further reading