PCBP1

PCBP1
Identifiers
Aliases	PCBP1, HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X, poly(rC) binding protein 1
External IDs	OMIM: 601209; MGI: 1345635; GeneCards: PCBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WVN, 1ZTG, 3VKE
Gene location (Human)
Chr.	Chromosome 2 (human)
End	70,089,203 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	86,503,303 bp
RNA expression pattern
	Top expressed in
	oocyte; ; gastrocnemius muscle; ; muscle of thigh; ; granulocyte; ; right adrenal gland; ; popliteal artery; ; tibial arteries; ; monocyte; ; right adrenal cortex; ; left adrenal gland;
	Top expressed in
	primitive streak; ; abdominal wall; ; hair follicle; ; migratory enteric neural crest cell; ; medullary collecting duct; ; renal corpuscle; ; endothelial cell of lymphatic vessel; ; mandibular prominence; ; dermis; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; mRNA binding; RNA binding; nucleic acid binding; single-stranded DNA binding; sequence-specific single stranded DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; cadherin binding;
Cellular component	cytoplasm; extracellular exosome; membrane; nucleus; nucleoplasm; cytosol; nuclear speck; cytoplasmic ribonucleoprotein granule;
Biological process	mRNA splicing, via spliceosome; viral RNA genome replication; positive regulation of transcription by RNA polymerase II; RNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5093
	23983
	ENSG00000169564
	ENSMUSG00000051695
	Q15365
	P60335
	NM_006196
	NM_011865
	NP_006187
	NP_035995
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP2 and HNRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.

It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169564 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051695 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tommerup N, Leffers H (May 1997). "Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A". Genomics. 32 (2): 297–8. doi:10.1006/geno.1996.0121. PMID 8833161.
↑ "Entrez Gene: PCBP1 poly(rC) binding protein 1".