PCDH8

PCDH8
Identifiers
Aliases	PCDH8, ARCADLIN, PAPC, protocadherin 8
External IDs	OMIM: 603580; MGI: 1306800; GeneCards: PCDH8
Gene location (Human)
Chr.	Chromosome 13 (human)
End	52,848,641 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	80,008,752 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; frontal pole; ; endothelial cell; ; middle temporal gyrus; ; Brodmann area 10; ; dorsolateral prefrontal cortex; ; primary visual cortex; ; Brodmann area 9; ; superior frontal gyrus; ; nucleus accumbens;
	Top expressed in
	anterior amygdaloid area; ; lateral septal nucleus; ; substantia nigra; ; subiculum; ; Region I of hippocampus proper; ; superior colliculus; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	cell projection; cell junction; postsynaptic membrane; plasma membrane; membrane; presynaptic membrane; integral component of membrane; synapse; dendrite; integral component of plasma membrane; glutamatergic synapse; integral component of postsynaptic membrane;
Biological process	morphogenesis of embryonic epithelium; somitogenesis; chemical synaptic transmission; homophilic cell adhesion via plasma membrane adhesion molecules; cell-cell signaling; cell adhesion; nervous system development; regulation of synaptic membrane adhesion;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5100
	18530
	ENSG00000136099
	ENSMUSG00000036422
	O95206
	Q7TSK3
	NM_032949; NM_002590
	NM_001042726; NM_021543
	NP_002581; NP_116567
	NP_001036191; NP_067518
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136099 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036422 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strehl S, Glatt K, Liu QM, Glatt H, Lalande M (Dec 1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics. 53 (1): 81–9. doi:10.1006/geno.1998.5467. PMID 9787079.
↑ Strehl S, LaSalle JM, Lalande M (Oct 1997). "High-resolution analysis of DNA replication domain organization across an R/G-band boundary". Mol Cell Biol. 17 (10): 6157–66. doi:10.1128/MCB.17.10.6157. PMC 232466. PMID 9315676.
1 2 "Entrez Gene: PCDH8 protocadherin 8".

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
Yamagata K, Andreasson KI, Sugiura H, et al. (1999). "Arcadlin is a neural activity-regulated cadherin involved in long term potentiation". J. Biol. Chem. 274 (27): 19473–1979. doi:10.1074/jbc.274.27.19473. PMID 10383464.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC 311048. PMID 11230163.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bray NJ, Kirov G, Owen RJ, et al. (2003). "Screening the human protocadherin 8 (PCDH8) gene in schizophrenia". Genes, Brain and Behavior. 1 (3): 187–91. doi:10.1034/j.1601-183X.2002.10307.x. PMID 12884975.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136099 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036422 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9787079-5] Strehl S, Glatt K, Liu QM, Glatt H, Lalande M (Dec 1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics. 53 (1): 81–9. doi:10.1006/geno.1998.5467. PMID 9787079.

[pmid9315676-6] Strehl S, LaSalle JM, Lalande M (Oct 1997). "High-resolution analysis of DNA replication domain organization across an R/G-band boundary". Mol Cell Biol. 17 (10): 6157–66. doi:10.1128/MCB.17.10.6157. PMC 232466. PMID 9315676.

[entrez-7] 1 2 "Entrez Gene: PCDH8 protocadherin 8".

PCDH8

References

Further reading