PCDHA4

PCDHA4
Identifiers
Aliases	PCDHA4, CNR1, CNRN1, CRNR1, PCDH-ALPHA4, protocadherin alpha 4
External IDs	OMIM: 606310; MGI: 1298406; GeneCards: PCDHA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WUZ
Gene location (Human)
Chr.	Chromosome 5 (human)
End	141,012,347 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	37,320,714 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; islet of Langerhans; ; prefrontal cortex; ; ganglionic eminence; ; gallbladder; ; superior frontal gyrus; ; ventricular zone; ; cerebellum; ; cerebellar cortex; ; cerebellar hemisphere;
	Top expressed in
	hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; granular layer; ; Cortex of frontal lobe; ; primary visual cortex; ; superior frontal gyrus; ; granular layer of dentate gyrus; ; Purkinje cell; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; calcium ion binding; metal ion binding; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; endoplasmic reticulum; synapse;
Biological process	cell adhesion; nervous system development; homophilic cell adhesion via plasma membrane adhesion molecules; cell-cell signaling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	56144
	12936
	ENSG00000204967
	ENSMUSG00000104252
	Q9UN74
	O88689
	NM_031500; NM_018907
	NM_007766
	NP_061730; NP_113688
	NP_001167625
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000204967 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000104252 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
↑ Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T (Apr 2000). "Genomic organization of the family of CNR cadherin genes in mice and humans". Genomics. 63 (1): 75–87. doi:10.1006/geno.1999.6066. PMID 10662547.
1 2 "Entrez Gene: PCDHA4 protocadherin alpha 4".

External links

Overview of all the structural information available in the PDB for UniProt: O88689 (Mouse Protocadherin alpha-4) at the PDBe-KB.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000204967 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000104252 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10380929-5] Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.

[pmid10662547-6] Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T (Apr 2000). "Genomic organization of the family of CNR cadherin genes in mice and humans". Genomics. 63 (1): 75–87. doi:10.1006/geno.1999.6066. PMID 10662547.

[entrez-7] 1 2 "Entrez Gene: PCDHA4 protocadherin alpha 4".

PCDHA4

References

Further reading

External links