PCNA-associated factor

PCLAF
Identifiers
Aliases	PCLAF, L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF, KIAA0101, PCNA clamp associated factor
External IDs	OMIM: 610696; MGI: 1915276; GeneCards: PCLAF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D2G
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,387,687 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,810,548 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; embryo; ; ventricular zone; ; ganglionic eminence; ; bone marrow; ; gingival epithelium; ; thymus; ; hair follicle; ; bone marrow cell; ; oral cavity;
	Top expressed in
	yolk sac; ; tail of embryo; ; somite; ; embryo; ; ventricular zone; ; genital tubercle; ; embryo; ; maxillary prominence; ; mandibular prominence; ; atrium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding; protein binding;
Cellular component	perinuclear region of cytoplasm; nucleus; nucleoplasm; cytoplasm; centrosome;
Biological process	DNA replication; translesion synthesis; response to UV; cellular response to DNA damage stimulus; regulation of cell cycle; DNA repair; centrosome cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9768
	68026
	ENSG00000166803
	ENSMUSG00000040204
	Q15004
	Q9CQX4
	NM_001029989; NM_014736
	NM_026515
	NP_001025160; NP_055551
	NP_080791
	Wikidata
View/Edit Human	View/Edit Mouse

PCNA-associated factor (also called “PCNA clamp associated factor”) is a protein that in humans is encoded by the PCLAF gene (previously KIAA0101). The PCLAF protein binds to PCNA and regulates DNA repair during DNA replication.

Interactions

PCLAF has been shown to interact with PCNA.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166803 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040204 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4): 484–9. doi:10.1038/sj.onc.1204113. PMID 11313979.
↑ Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C (Jan 2006). "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research. 312 (1): 73–85. doi:10.1016/j.yexcr.2005.09.020. PMID 16288740.
↑ "Entrez Gene: KIAA0101 KIAA0101".
↑ "Q15004 · PAF15_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-03.

Shi L, Zhang SL, Li K, Hong Y, Wang Q, Li Y, Guo J, Fan WH, Zhang L, Cheng J (Feb 2008). "NS5ATP9, a gene up-regulated by HCV NS5A protein". Cancer Letters. 259 (2): 192–7. doi:10.1016/j.canlet.2007.10.029. PMID 18068894.
Guo M, Li J, Wan D, Gu J (2006). "KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma". BMC Cancer. 6 109. doi:10.1186/1471-2407-6-109. PMC 1483895. PMID 16646990.
Mizutani K, Onda M, Asaka S, Akaishi J, Miyamoto S, Yoshida A, Nagahama M, Ito K, Emi M (May 2005). "Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma". Cancer. 103 (9): 1785–90. doi:10.1002/cncr.20988. PMID 15789362.
Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, Law CL, Wahl A, Carter P (Oct 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166803 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040204 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11313979-5] 1 2 Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4): 484–9. doi:10.1038/sj.onc.1204113. PMID 11313979.

[pmid16288740-6] Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C (Jan 2006). "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research. 312 (1): 73–85. doi:10.1016/j.yexcr.2005.09.020. PMID 16288740.

[entrez-7] "Entrez Gene: KIAA0101 KIAA0101".

[8] "Q15004 · PAF15_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-03.

PCNA-associated factor

Interactions

References

Further reading