PCOLCE
Protein-coding gene in humans
Procollagen C-endopeptidase enhancer 1 is an enzyme that in humans is encoded by the PCOLCE gene .
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens . These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides , respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils . This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens activity.
References
1 2 3 GRCh38: Ensembl release 89: ENSG00000106333 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029718 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Takahara K, Osborne L, Elliott RW, Tsui LC, Scherer SW, Greenspan DS (Mar 1997). "Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics . 31 (2): 253– 256. doi :10.1006/geno.1996.0043 . PMID 8824813 . ↑ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes" . Genome Res . 8 (10): 1060– 1073. doi :10.1101/gr.8.10.1060 . PMC 310788 PMID 9799793 . 1 2 "Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer" .
Further reading
Takahara K, Kessler E, Biniaminov L, et al. (1994). "Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE)" . J. Biol. Chem . 269 (42): 26280– 26285. doi :10.1016/S0021-9258(18)47191-8 PMID 7523404 . Scott IC, Clark TG, Takahara K, et al. (1999). "Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics . 55 (2): 229– 234. doi :10.1006/geno.1998.5663 . PMID 9933570 . Mott JD, Thomas CL, Rosenbach MT, et al. (2000). "Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor" . J. Biol. Chem . 275 (2): 1384– 1390. doi :10.1074/jbc.275.2.1384 PMID 10625689 . Ricard-Blum S, Bernocco S, Font B, et al. (2002). "Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1" . J. Biol. Chem . 277 (37): 33864– 33869. doi :10.1074/jbc.M205018200 PMID 12105202 . Ligon AH, Scott IC, Takahara K, et al. (2002). "PCOLCE deletion and expression analyses in uterine leiomyomata". Cancer Genet. Cytogenet . 137 (2): 133– 137. doi :10.1016/S0165-4608(02)00547-2 . PMID 12393284 . Steiglitz BM, Keene DR, Greenspan DS (2003). "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1" . J. Biol. Chem . 277 (51): 49820– 49830. doi :10.1074/jbc.M209891200 PMID 12393877 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Bernocco S, Steiglitz BM, Svergun DI, et al. (2003). "Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein" . J. Biol. Chem . 278 (9): 7199– 7205. doi :10.1074/jbc.M210857200 PMID 12486138 . Liepinsh E, Banyai L, Pintacuda G, et al. (2003). "NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding" . J. Biol. Chem . 278 (28): 25982– 25989. doi :10.1074/jbc.M302734200 PMID 12670942 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Petropoulou V, Garrigue-Antar L, Kadler KE (2005). "Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1)" . J. Biol. Chem . 280 (24): 22616– 22623. doi :10.1074/jbc.M413468200 PMID 15817489 . Ge G, Zhang Y, Steiglitz BM, Greenspan DS (2006). "Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains" . J. Biol. Chem . 281 (16): 10786– 10798. doi :10.1074/jbc.M511111200 PMID 16507574 . Blanc G, Font B, Eichenberger D, et al. (2007). "Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity" (PDF) . J. Biol. Chem . 282 (23): 16924– 16933. doi :10.1074/jbc.M701610200 PMID 17446170 . Archived from the original
