PCYOX1

PCYOX1

Identifiers

PCYOX1, PCL1, prenylcysteine oxidase 1

External IDs

OMIM: 610995; MGI: 1914131; GeneCards: PCYOX1

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
1.8.3.5	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2p13.3	Start	70,257,386 bp
Band	2p13.3	End	70,281,185 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6\|6 D1	Start	86,362,988 bp
Band	6\|6 D1	End	86,374,136 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

parotid gland

endothelial cell

parietal pleura

skin of hip

gingival epithelium

skin of thigh

Skeletal muscle tissue of biceps brachii

Skeletal muscle tissue of rectus abdominis

Brodmann area 23

visceral pleura

Top expressed in

urothelium

medullary collecting duct

transitional epithelium of urinary bladder

facial motor nucleus

cumulus cell

ureter

vestibular sensory epithelium

substantia nigra

Epithelium of choroid plexus

skin of external ear

More reference expression data


More reference expression data

Gene ontology
Molecular function	oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor prenylcysteine oxidase activity
Cellular component	plasma membrane extracellular exosome vacuolar membrane very-low-density lipoprotein particle lysosome
Biological process	prenylcysteine metabolic process chloride transport chloride transmembrane transport prenylcysteine catabolic process prenylated protein catabolic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


51449


66881


ENSG00000116005


ENSMUSG00000029998


Q9UHG3


Q9CQF9

RefSeq (mRNA)


NM_016297


NM_025823 NM_001355687

RefSeq (protein)


NP_057381


NP_080099 NP_001342616

Location (UCSC)

Chr 2: 70.26 – 70.28 Mb

Chr 6: 86.36 – 86.37 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Prenylcysteine oxidase 1 is an enzyme that in humans is encoded by the PCYOX1 gene.

See also

Prenylcysteine oxidase

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116005 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029998 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tschantz WR, Zhang L, Casey PJ (Jan 2000). "Cloning, expression, and cellular localization of a human prenylcysteine lyase". J Biol Chem. 274 (50): 35802–8. doi:10.1074/jbc.274.50.35802. PMID 10585463.
↑ Digits JA, Pyun HJ, Coates RM, Casey PJ (Oct 2002). "Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase". J Biol Chem. 277 (43): 41086–93. doi:10.1074/jbc.M208069200. PMID 12186880.
↑ "Entrez Gene: PCYOX1 prenylcysteine oxidase 1".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Zhang L, Tschantz WR, Casey PJ (1997). "Isolation and characterization of a prenylcysteine lyase from bovine brain". J. Biol. Chem. 272 (37): 23354–9. doi:10.1074/jbc.272.37.23354. PMID 9287348.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Wouters MM, Neefs JM, Kerchove d'Exaerde A, et al. (2006). "Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse jejunum". Biochem. Biophys. Res. Commun. 346 (2): 491–500. doi:10.1016/j.bbrc.2006.05.132. PMID 16765319. S2CID 21347125.

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