PCYT1B

PCYT1B

Identifiers

PCYT1B, CCTB, CTB, phosphate cytidylyltransferase 1, choline, beta, phosphate cytidylyltransferase 1B, choline

External IDs

OMIM: 300948; MGI: 2147987; GeneCards: PCYT1B

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
2.7.7.15	↗	↗	↗	↗

Gene location (Human)

Chr.	X chromosome (human)

Band	Xp22.11	Start	24,558,087 bp
Band	Xp22.11	End	24,672,677 bp

Gene location (Mouse)

Chr.	X chromosome (mouse)

Band	X\|X C3	Start	92,698,469 bp
Band	X\|X C3	End	92,793,557 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ventricular zone

ganglionic eminence

prefrontal cortex

C1 segment

amygdala

nucleus accumbens

left testis

cingulate gyrus

anterior cingulate cortex

right testis

Top expressed in

zygote

secondary oocyte

otolith organ

utricle

ganglionic eminence

dentate gyrus of hippocampal formation granule cell

piriform cortex

otic vesicle

respiratory epithelium

olfactory epithelium

More reference expression data


More reference expression data

Gene ontology
Molecular function	nucleotidyltransferase activity catalytic activity transferase activity choline-phosphate cytidylyltransferase activity phosphatidylcholine binding
Cellular component	endoplasmic reticulum membrane cytoplasm endoplasmic reticulum
Biological process	phospholipid biosynthetic process phosphatidylcholine biosynthetic process biosynthetic process spermatogenesis ovarian follicle development lipid metabolism CDP-choline pathway
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9468


236899


ENSG00000102230


ENSMUSG00000035246


Q9Y5K3


Q811Q9

RefSeq (mRNA)


NM_001163264 NM_001163265 NM_004845


NM_177546 NM_211138

RefSeq (protein)


NP_001156736 NP_001156737 NP_004836


NP_808214 NP_997593

Location (UCSC)

Chr X: 24.56 – 24.67 Mb

Chr X: 92.7 – 92.79 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Choline-phosphate cytidylyltransferase B is an enzyme that in humans is encoded by the PCYT1B gene.

See also

Choline-phosphate cytidylyltransferase

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102230 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035246 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lykidis A, Murti KG, Jackowski S (Jul 1998). "Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase". J Biol Chem. 273 (22): 14022–9. doi:10.1074/jbc.273.22.14022. PMID 9593753.
↑ "Entrez Gene: PCYT1B phosphate cytidylyltransferase 1, choline, beta".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Llorca O, Martín-Benito J, Gómez-Puertas P, et al. (2002). "Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin". J. Struct. Biol. 135 (2): 205–18. doi:10.1006/jsbi.2001.4359. PMID 11580270.
McCormack EA, Llorca O, Carrascosa JL, et al. (2002). "Point mutations in a hinge linking the small and large domains of beta-actin result in trapped folding intermediates bound to cytosolic chaperonin CCT". J. Struct. Biol. 135 (2): 198–204. doi:10.1006/jsbi.2001.4385. PMID 11580269.
Lykidis A, Baburina I, Jackowski S (1999). "Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant". J. Biol. Chem. 274 (38): 26992–7001. doi:10.1074/jbc.274.38.26992. PMID 10480912.
Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.

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