PDCD6IP
Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.
This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.
Function
PDCD6IP protein is part of ESCRT pathway. It participates in the membrane scission of the revers topology budding and participates in multivesicular body formation. It is also vital at the later stages and for successful completion of cytokinesis.
Interactions
PDCD6IP has been shown to interact with PDCD6. The V domain of PDCD6IP recognises Short linear motif LYPxLxxL and this motif is mimicked by p6 late domain of HIV and related viruses which facilitates viral hijacking of ESCRT pathway and consequential budding of viral particles.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000170248 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032504 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 Vito P, Pellegrini L, Guiet C, D'Adamio L (February 1999). "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction". The Journal of Biological Chemistry. 274 (3): 1533–1540. doi:10.1074/jbc.274.3.1533. PMID 9880530.
- 1 2 "Entrez Gene: PDCD6IP programmed cell death 6 interacting protein".
- ↑ Vietri M, Radulovic M, Stenmark H (January 2020). "The many functions of ESCRTs". Nature Reviews. Molecular Cell Biology. 21 (1): 25–42. doi:10.1038/s41580-019-0177-4. PMID 31705132. S2CID 207939465.
- ↑ Carlton JG, Martin-Serrano J (June 2007). "Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery". Science. 316 (5833). New York, N.Y.: 1908–1912. Bibcode:2007Sci...316.1908C. doi:10.1126/science.1143422. PMID 17556548. S2CID 29191843.
- ↑ Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M (March 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochemical and Biophysical Research Communications. 291 (5): 1166–1172. doi:10.1006/bbrc.2002.6600. PMID 11883939.
- ↑ Votteler J, Sundquist WI (September 2013). "Virus budding and the ESCRT pathway". Cell Host & Microbe. 14 (3): 232–241. doi:10.1016/j.chom.2013.08.012. PMC 3819203. PMID 24034610.
Further reading
- Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, et al. (June 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Molecular and Cellular Neurosciences. 11 (3): 149–160. doi:10.1006/mcne.1998.0677. PMID 9647693. S2CID 20003277.
- Missotten M, Nichols A, Rieger K, Sadoul R (1999). "Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein". Cell Death and Differentiation. 6 (2): 124–129. doi:10.1038/sj.cdd.4400456. PMID 10200558.
- Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Wu Y, Pan S, Che S, He G, Nelman-Gonzalez M, Weil MM, et al. (June 2001). "Overexpression of Hp95 induces G1 phase arrest in confluent HeLa cells". Differentiation; Research in Biological Diversity. 67 (4–5): 139–153. doi:10.1046/j.1432-0436.2001.670406.x. PMID 11683497.
- Chatellard-Causse C, Blot B, Cristina N, Torch S, Missotten M, Sadoul R (August 2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization". The Journal of Biological Chemistry. 277 (32): 29108–29115. doi:10.1074/jbc.M204019200. PMID 12034747.
- Wu Y, Pan S, Luo W, Lin SH, Kuang J (October 2002). "Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells". Oncogene. 21 (44): 6801–6808. doi:10.1038/sj.onc.1205849. PMID 12360406.
- Vincent O, Rainbow L, Tilburn J, Arst HN, Peñalva MA (March 2003). "YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix". Molecular and Cellular Biology. 23 (5): 1647–1655. doi:10.1128/MCB.23.5.1647-1655.2003. PMC 151718. PMID 12588984.
- Schmidt MH, Chen B, Randazzo LM, Bogler O (2004). "SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion". Journal of Cell Science. 116 (Pt 14): 2845–2855. doi:10.1242/jcs.00522. PMID 12771190. S2CID 6863972.
- Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, et al. (October 2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". The Journal of Biological Chemistry. 278 (40): 39104–39113. doi:10.1074/jbc.M301604200. PMID 12860994.
- Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
- Strack B, Calistri A, Craig S, Popova E, Göttlinger HG (September 2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–699. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
- von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, et al. (September 2003). "The protein network of HIV budding". Cell. 114 (6): 701–713. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
- Martin-Serrano J, Yarovoy A, Perez-Caballero D, Bieniasz PD (October 2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12414–12419. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
- Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". The Biochemical Journal. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
- Katoh K, Shibata H, Hatta K, Maki M (2004). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Archives of Biochemistry and Biophysics. 421 (1): 159–165. doi:10.1016/j.abb.2003.09.038. PMID 14678797.
- Matsuo H, Chevallier J, Mayran N, Le Blanc I, Ferguson C, Fauré J, et al. (January 2004). "Role of LBPA and Alix in multivesicular liposome formation and endosome organization". Science. 303 (5657). New York, N.Y.: 531–534. Bibcode:2004Sci...303..531M. doi:10.1126/science.1092425. PMID 14739459. S2CID 36353407.
External links
- PDCD6IP human gene location in the UCSC Genome Browser.
- PDCD6IP human gene details in the UCSC Genome Browser.
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