| Phorbol-diester hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.51 | ||||||||
| CAS no. | 81181-74-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Phorbol-diester hydrolase (EC 3.1.1.51) is an enzyme that catalyzes the reaction
The enzyme characterised from murine liver hydrolyses the diterpenoid, phorbol 12,13-dibutyrate, to remove one specific butyrate ester, giving phorbol 13-butanoate and butyric acid. It also acts on 12-O-tetradecanoylphorbol-13-acetate. Such phorbol diesters from croton oil are tumor promoters, so this reaction inactivates them.
This enzyme is a hydrolase, specifically one acting on carboxylic ester bonds. The systematic name is 12,13-diacylphorbate 12-acylhydrolase. Other names in common use include diacylphorbate 12-hydrolase, diacylphorbate 12-hydrolase, phorbol-12,13-diester 12-ester hydrolase, and PDEH.
