PDS5A

PDS5A

Identifiers

PDS5A, SCC-112, SCC112, PIG54, PDS5 cohesin associated factor A

External IDs

OMIM: 613200; MGI: 1918771; GeneCards: PDS5A

Gene location (Human)

Chr.	Chromosome 4 (human)

Band	4p14	Start	39,822,863 bp
Band	4p14	End	39,977,956 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 C3.1	Start	65,763,064 bp
Band	5\|5 C3.1	End	65,855,616 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

germinal epithelium

epithelium of nasopharynx

Achilles tendon

tonsil

gingival epithelium

epithelium of colon

Epithelium of choroid plexus

cartilage tissue

seminal vesicula

bone marrow cell

Top expressed in

tail of embryo

genital tubercle

ventricular zone

epiblast

primitive streak

thymus

lacrimal gland

cumulus cell

renal corpuscle

Paneth cell

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	cytosol chromatin plasma membrane chromosome, centromeric region nucleoplasm chromosome nucleus
Biological process	cell division cell cycle negative regulation of DNA replication mitotic sister chromatid cohesion DNA repair
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23244


71521


ENSG00000121892


ENSMUSG00000029202


Q29RF7


Q6A026

RefSeq (mRNA)


NM_001100399 NM_001100400 NM_015200


NM_001081321 NM_027818

RefSeq (protein)


NP_001093869 NP_001093870


n/a

Location (UCSC)

Chr 4: 39.82 – 39.98 Mb

Chr 5: 65.76 – 65.86 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000121892 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029202 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (Dec 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
↑ Losada A, Yokochi T, Hirano T (May 2005). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". J Cell Sci. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.
↑ "Entrez Gene: SCC-112 SCC-112 protein".

Further reading

Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Gregson HC, Schmiesing JA, Kim JS, et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly". J. Biol. Chem. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kumar D, Sakabe I, Patel S, et al. (2004). "SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas". Gene. 328: 187–96. doi:10.1016/j.gene.2003.12.013. PMID 15019998.
Rankin S, Ayad NG, Kirschner MW (2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol. Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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