PDZRN3

PDZRN3

Identifiers

PDZRN3, LNX3, SEMACAP3, SEMCAP3, PDZ domain containing ring finger 3

External IDs

OMIM: 609729; MGI: 1933157; GeneCards: PDZRN3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1UHP, 1WH1

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
2.3.2.27	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 3 (human)

Band	3p13	Start	73,382,431 bp
Band	3p13	End	73,624,941 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6\|6 D3	Start	101,126,570 bp
Band	6\|6 D3	End	101,354,858 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

hair follicle

gastric mucosa

urethra

vastus lateralis muscle

seminal vesicula

cartilage tissue

saphenous vein

myocardium of left ventricle

right ventricle

tibia

Top expressed in

molar

soleus muscle

tibialis anterior muscle

vastus lateralis muscle

gastrocnemius muscle

umbilical cord

atrioventricular valve

medial head of gastrocnemius muscle

triceps brachii muscle

sternocleidomastoid muscle

More reference expression data


More reference expression data

Gene ontology
Molecular function	zinc ion binding metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity
Cellular component	neuromuscular junction nucleus nucleoplasm cytosol cytoplasm cell junction synapse
Biological process	neuromuscular junction development protein ubiquitination
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23024


55983


ENSG00000121440


ENSMUSG00000035357


Q9UPQ7


Q69ZS0

RefSeq (mRNA)


NM_015009 NM_001303139 NM_001303140 NM_001303141 NM_001303142


NM_018884

RefSeq (protein)


NP_001290068 NP_001290069 NP_001290070 NP_001290071 NP_055824


NP_061372

Location (UCSC)

Chr 3: 73.38 – 73.62 Mb

Chr 6: 101.13 – 101.35 Mb

PubMed search

View/Edit Human

View/Edit Mouse

PDZ domain-containing RING finger protein 3 is a protein that in humans is encoded by the PDZRN3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000121440 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035357 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
↑ "Entrez Gene: PDZRN3 PDZ domain containing RING finger 3".

Further reading

Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247. S2CID 22326394.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Katoh M, Katoh M (2004). "Identification and characterization of PDZRN3 and PDZRN4 genes in silico". Int. J. Mol. Med. 13 (4): 607–13. doi:10.3892/ijmm.13.4.607. PMID 15010864.
Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.
Santin AD, Zhan F, Bellone S, et al. (2004). "Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy". Int. J. Cancer. 112 (1): 14–25. doi:10.1002/ijc.20408. PMID 15305371. S2CID 29845339.
Meyer G, Varoqueaux F, Neeb A, et al. (2005). "The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin". Neuropharmacology. 47 (5): 724–33. doi:10.1016/j.neuropharm.2004.06.023. PMID 15458844. S2CID 11771522.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

v t e PDB gallery
1uhp: Solution structure of RSGI RUH-005, a PDZ domain in human cDNA, KIAA1095 1wh1: Solution structure of the fourth PDZ domain of KIAA1095 protein

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