PHF12

PHF12

Identifiers

PHF12, PF1, PHD finger protein 12

External IDs

MGI: 1924057; GeneCards: PHF12

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2L9S, 2LKM

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17q11.2	Start	28,905,250 bp
Band	17q11.2	End	28,951,771 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11\|11 B5	Start	77,873,580 bp
Band	11\|11 B5	End	77,921,365 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

sural nerve

granulocyte

bone marrow cell

stromal cell of endometrium

spleen

right lung

blood

appendix

gastric mucosa

ganglionic eminence

Top expressed in

genital tubercle

tail of embryo

neural layer of retina

granulocyte

ventricular zone

zygote

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

thymus

secondary oocyte

More reference expression data


More reference expression data

Gene ontology
Molecular function	transcription corepressor binding histone binding transcription corepressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding protein binding phosphatidylinositol binding metal ion binding
Cellular component	transcription repressor complex Sin3 complex nucleus nucleoplasm Sin3-type complex
Biological process	negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


57649


268448


ENSG00000109118


ENSMUSG00000037791


Q96QT6


Q5SPL2

RefSeq (mRNA)


NM_001033561 NM_001290131 NM_020889


NM_174852

RefSeq (protein)


NP_001028733 NP_001277060 NP_065940


NP_777277

Location (UCSC)

Chr 17: 28.91 – 28.95 Mb

Chr 11: 77.87 – 77.92 Mb

PubMed search

View/Edit Human

View/Edit Mouse

PHD finger protein 12 is a protein that in humans is encoded by the PHF12 gene.

Interactions

PHF12 has been shown to interact with SIN3A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109118 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037791 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Yochum GS, Ayer DE (July 2001). "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex". Molecular and Cellular Biology. 21 (13): 4110–8. doi:10.1128/MCB.21.13.4110-4118.2001. PMC 87072. PMID 11390640.
↑ "Entrez Gene: PHF12 PHD finger protein 12".

Further reading

Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Yochum GS, Ayer DE (November 2002). "Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Molecular and Cellular Biology. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" (PDF). DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. S2CID 43194324.

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