PHLPP1

PHLPP1

Identifiers

PHLPP1, PHLPP, PLEKHE1, SCOP, PPM3A, PH domain and leucine rich repeat protein phosphatase 1

External IDs

OMIM: 609396; MGI: 2138327; GeneCards: PHLPP1

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
3.1.3.16	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 18 (human)

Band	18q21.33	Start	62,715,541 bp
Band	18q21.33	End	62,980,433 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1\|1 E2.1	Start	106,099,482 bp
Band	1\|1 E2.1	End	106,321,980 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

corpus callosum

ventricular zone

internal globus pallidus

middle frontal gyrus

inferior ganglion of vagus nerve

optic nerve

ganglionic eminence

buccal mucosa cell

Region I of hippocampus proper

external globus pallidus

Top expressed in

deep cerebellar nuclei

lateral geniculate nucleus

globus pallidus

substantia nigra

medial geniculate nucleus

pontine nuclei

dorsal tegmental nucleus

medial dorsal nucleus

mammillary body

superior colliculus

More reference expression data


More reference expression data

Gene ontology
Molecular function	phosphoprotein phosphatase activity metal ion binding protein binding catalytic activity hydrolase activity protein serine/threonine phosphatase activity
Cellular component	cytosol membrane nucleus cytoplasm plasma membrane nuclear membrane photoreceptor inner segment photoreceptor outer segment membrane
Biological process	regulation of apoptotic process regulation of MAPK cascade protein dephosphorylation entrainment of circadian clock regulation of JNK cascade regulation of T cell anergy regulation of p38MAPK cascade apoptotic process regulation of protein kinase C signaling negative regulation of protein kinase B signaling
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23239


98432


ENSG00000081913


ENSMUSG00000044340


O60346


Q8CHE4

RefSeq (mRNA)


NM_194449


NM_133821

RefSeq (protein)


NP_919431


NP_598582

Location (UCSC)

Chr 18: 62.72 – 62.98 Mb

Chr 1: 106.1 – 106.32 Mb

PubMed search

View/Edit Human

View/Edit Mouse

PH domain leucine-rich repeat-containing protein phosphatase 1, also known as PHLPP1, is an enzyme which in humans is encoded by the PHLPP1 gene (previously PHLPP). It is part of the serine/threonine phosphatase family.

See also

PHLPP

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000081913 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044340 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: PHLPP PH domain and leucine rich repeat protein phosphatase".

Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Shimizu K, Okada M, Takano A, Nagai K (2000). "SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus". FEBS Lett. 458 (3): 363–9. doi:10.1016/S0014-5793(99)01190-4. PMID 10570941. S2CID 38044717.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gao T, Furnari F, Newton AC (2005). "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth". Mol. Cell. 18 (1): 13–24. doi:10.1016/j.molcel.2005.03.008. PMID 15808505.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18". Nature. 437 (7058): 551–5. Bibcode:2005Natur.437..551N. doi:10.1038/nature03983. PMID 16177791.
Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms". Mol. Cell. 25 (6): 917–31. doi:10.1016/j.molcel.2007.02.017. PMID 17386267.

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