PIK3AP1

PIK3AP1

Identifiers

PIK3AP1, BCAP, phosphoinositide-3-kinase adaptor protein 1

External IDs

OMIM: 607942; MGI: 1933177; GeneCards: PIK3AP1

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	10q24.1	Start	96,593,315 bp
Band	10q24.1	End	96,720,514 bp

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)

Band	19\|19 C3	Start	41,260,816 bp
Band	19\|19 C3	End	41,373,541 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

parotid gland

pancreatic epithelial cell

monocyte

pancreatic ductal cell

mucosa of ileum

appendix

blood

trabecular bone

bone marrow

granulocyte

Top expressed in

granulocyte

submandibular gland

spleen

vestibular sensory epithelium

blood

Paneth cell

liver

right lung lobe

vestibular membrane of cochlear duct

lymph node

More reference expression data

n/a

Gene ontology
Molecular function	phosphatidylinositol 3-kinase regulatory subunit binding identical protein binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity signaling receptor binding
Cellular component	cytoplasm cytosol plasma membrane membrane
Biological process	positive regulation of phosphatidylinositol 3-kinase signaling toll-like receptor 9 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor 7 signaling pathway regulation of inflammatory response phosphatidylinositol phosphate biosynthetic process positive regulation of protein kinase B signaling
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


118788


83490


ENSG00000155629


ENSMUSG00000025017


Q6ZUJ8


Q9EQ32

RefSeq (mRNA)


NM_152309


NM_031376

RefSeq (protein)


NP_689522


NP_113553

Location (UCSC)

Chr 10: 96.59 – 96.72 Mb

Chr 19: 41.26 – 41.37 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Phosphoinositide 3-kinase adapter protein 1 is an enzyme that in humans is encoded by the PIK3AP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155629 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025017 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Edwards JA, Sethi PK, Scoma AJ, Bannerman RM, Frohman LA (Apr 1976). "A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance". Am J Med. 60 (1): 23–32. doi:10.1016/0002-9343(76)90529-5. PMID 1251844.
↑ Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T (Jan 2001). "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation". Immunity. 13 (6): 817–27. doi:10.1016/S1074-7613(00)00079-0. PMID 11163197.
↑ "Entrez Gene: PIK3AP1 phosphoinositide-3-kinase adaptor protein 1".

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Maruoka M, Suzuki J, Kawata S, et al. (2005). "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases". FEBS Lett. 579 (14): 2986–90. doi:10.1016/j.febslet.2005.04.052. PMID 15893754. S2CID 20802390.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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