PIK3R3

PIK3R3

Identifiers

PIK3R3, p55, p55-GAMMA, p55PIK, phosphoinositide-3-kinase regulatory subunit 3, PI3KR3

External IDs

OMIM: 606076; MGI: 109277; GeneCards: PIK3R3

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p34.1	Start	46,040,140 bp
Band	1p34.1	End	46,133,036 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4\|4 D1	Start	116,078,815 bp
Band	4\|4 D1	End	116,160,253 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

cerebellar vermis

paraflocculus of cerebellum

nasal epithelium

lower lobe of lung

right hemisphere of cerebellum

mucosa of paranasal sinus

right ventricle

right lung

testicle

ganglionic eminence

Top expressed in

cerebellar vermis

lobe of cerebellum

zygote

hand

ganglionic eminence

otic vesicle

inferior colliculi

suprachiasmatic nucleus

pontine nuclei

secondary oocyte

More reference expression data


More reference expression data

Gene ontology
Molecular function	phosphatidylinositol 3-kinase regulator activity protein binding 1-phosphatidylinositol-3-kinase activity phosphotyrosine residue binding 1-phosphatidylinositol-3-kinase regulator activity
Cellular component	cytosol phosphatidylinositol 3-kinase complex
Biological process	regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol-3-phosphate biosynthetic process insulin receptor signaling pathway positive regulation of protein phosphorylation cell migration involved in sprouting angiogenesis positive regulation of gene expression protein kinase B signaling positive regulation of cell migration phosphatidylinositol phosphate biosynthetic process phosphatidylinositol biosynthetic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


8503


18710


ENSG00000117461


ENSMUSG00000028698


Q92569


Q64143

RefSeq (mRNA)

NM_001114172 NM_001303428 NM_001303429 NM_001328648 NM_001328649
NM_001328650 NM_001328651 NM_001328652 NM_001328653 NM_001328654 NM_003629


NM_181585 NM_001355584 NM_001355585 NM_001355586

RefSeq (protein)

NP_001107644 NP_001290357 NP_001290358 NP_001315577 NP_001315578
NP_001315579 NP_001315580 NP_001315581 NP_001315582 NP_001315583 NP_003620


NP_853616 NP_001342513 NP_001342514 NP_001342515

Location (UCSC)

Chr 1: 46.04 – 46.13 Mb

Chr 4: 116.08 – 116.16 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.

Interactions

PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor, IRS1 and Retinoblastoma protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117461 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028698 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dey BR, Furlanetto RW, Nissley SP (May 1998). "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor". Gene. 209 (1–2): 175–83. doi:10.1016/S0378-1119(98)00045-6. PMID 9524259.
↑ "Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)".
1 2 Mothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. ISSN 0888-8809. PMID 9415396.
↑ Xia, X; Serrero G (Aug 1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. ISSN 0264-6021. PMC 1220424. PMID 10417350.
↑ Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. ISSN 0270-7306. PMC 151709. PMID 12588990.

Further reading

Pons S, Asano T, Glasheen E, et al. (1995). "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase". Mol. Cell. Biol. 15 (8): 4453–65. doi:10.1128/MCB.15.8.4453. PMC 230685. PMID 7542745.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Tuscano JM, Engel P, Tedder TF, et al. (1996). "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22". Eur. J. Immunol. 26 (6): 1246–52. doi:10.1002/eji.1830260610. PMID 8647200. S2CID 29471624.
Takahashi-Tezuka M, Hibi M, Fujitani Y, et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
Mothe I, Delahaye L, Filloux C, et al. (1998). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. PMID 9415396.
Xia X, Serrero G (1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. PMC 1220424. PMID 10417350.
Inukai K, Funaki M, Anai M, et al. (2001). "Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations". FEBS Lett. 490 (1–2): 32–8. doi:10.1016/S0014-5793(01)02132-9. PMID 11172806.
Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Xia X, Cheng A, Akinmade D, Hamburger AW (2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. PMC 151709. PMID 12588990.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Soroceanu L, Kharbanda S, Chen R, et al. (2007). "Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3466–71. Bibcode:2007PNAS..104.3466S. doi:10.1073/pnas.0611271104. PMC 1802005. PMID 17360667.
Kallin A, Johannessen LE, Cani PD, et al. (2007). "SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma". J. Lipid Res. 48 (7): 1628–36. doi:10.1194/jlr.M700136-JLR200. PMID 17452746.

v t e PDB gallery
2pna: STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE 2pnb: STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE

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