PIK3R5

PIK3R5

Identifiers

PIK3R5, F730038I15Rik, FOAP-2, P101-PI3K, p101, phosphoinositide-3-kinase regulatory subunit 5

External IDs

OMIM: 611317; MGI: 2443588; GeneCards: PIK3R5

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17p13.1	Start	8,878,911 bp
Band	17p13.1	End	8,965,712 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11\|11 B3	Start	68,322,947 bp
Band	11\|11 B3	End	68,388,675 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

granulocyte

blood

monocyte

spleen

bone marrow cell

upper lobe of left lung

lymph node

right lung

appendix

gallbladder

Top expressed in

granulocyte

thymus

blood

mesenteric lymph nodes

stroma of bone marrow

spleen

outer nuclear layer

otic vesicle

subcutaneous adipose tissue

lumbar subsegment of spinal cord

More reference expression data


More reference expression data

Gene ontology
Molecular function	G-protein beta/gamma-subunit complex binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase regulator activity
Cellular component	cytoplasm plasma membrane phosphatidylinositol 3-kinase complex, class IB membrane nucleus phosphatidylinositol 3-kinase complex microtubule organizing center cytosol
Biological process	platelet activation positive regulation of protein kinase B signaling regulation of phosphatidylinositol 3-kinase activity positive regulation of MAP kinase activity phosphatidylinositol 3-kinase signaling phosphatidylinositol phosphate biosynthetic process G protein-coupled receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase signaling phosphatidylinositol biosynthetic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23533


320207


ENSG00000141506


ENSMUSG00000020901


Q8WYR1


Q5SW28

RefSeq (mRNA)

NM_001142633 NM_001251851 NM_001251852 NM_001251853 NM_001251855
NM_014308 NM_001388396 NM_001388397 NM_001388398 NM_001388399 NM_001388400


NM_177320

RefSeq (protein)

NP_001136105 NP_001238780 NP_001238781 NP_001238782 NP_001238784
NP_055123


NP_796294.2 NP_796294

Location (UCSC)

Chr 17: 8.88 – 8.97 Mb

Chr 11: 68.32 – 68.39 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.

Interactions

PIK3R5 has been shown to interact with PIK3CG.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141506 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020901 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Brock C, Schaefer M, Reusch HP, et al. (Jan 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J Cell Biol. 160 (1): 89–99. doi:10.1083/jcb.200210115. PMC 2172741. PMID 12507995.
↑ "Entrez Gene: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5, p101".

Further reading

Johnson C, Marriott SJ, Levy LS (2007). "Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival". Oncogene. 26 (49): 7049–57. doi:10.1038/sj.onc.1210504. PMID 17486067.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Suire S, Coadwell J, Ferguson GJ, et al. (2005). "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma". Curr. Biol. 15 (6): 566–70. Bibcode:2005CBio...15..566S. doi:10.1016/j.cub.2005.02.020. PMID 15797027. S2CID 12255918.
Voigt P, Brock C, Nürnberg B, et al. (2005). "Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma". J. Biol. Chem. 280 (6): 5121–7. doi:10.1074/jbc.M413104200. PMID 15611065.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Metjian A, Roll RL, Ma AD, et al. (1999). "Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus". J. Biol. Chem. 274 (39): 27943–7. doi:10.1074/jbc.274.39.27943. PMID 10488142.
Krugmann S, Hawkins PT, Pryer N, et al. (1999). "Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits". J. Biol. Chem. 274 (24): 17152–8. doi:10.1074/jbc.274.24.17152. PMID 10358071.

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